C
Clemens Schafmayer
Researcher at University of Kiel
Publications - 172
Citations - 9585
Clemens Schafmayer is an academic researcher from University of Kiel. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 41, co-authored 153 publications receiving 7722 citations. Previous affiliations of Clemens Schafmayer include Leipzig University.
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Journal ArticleDOI
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
Simone Wahl,Alexander W. Drong,Benjamin Lehne,Marie Loh,Marie Loh,Marie Loh,William R. Scott,William R. Scott,Sonja Kunze,Pei-Chien Tsai,Janina S. Ried,Weihua Zhang,Weihua Zhang,Youwen Yang,Sili Tan,Giovanni Fiorito,Lude Franke,Simonetta Guarrera,Silva Kasela,Jennifer Kriebel,Rebecca C Richmond,Marco Adamo,Uzma Afzal,Uzma Afzal,Mika Ala-Korpela,Mika Ala-Korpela,Mika Ala-Korpela,Benedetta Albetti,Ole Ammerpohl,Jane F. Apperley,Marian Beekman,Pier Alberto Bertazzi,S. Lucas Black,Christine Blancher,Marc Jan Bonder,Mario Brosch,Maren Carstensen-Kirberg,Anton J. M. de Craen,Simon de Lusignan,Abbas Dehghan,Mohamed Elkalaawy,Krista Fischer,Oscar H. Franco,Tom R. Gaunt,Jochen Hampe,Majid Hashemi,Aaron Isaacs,Andrew Jenkinson,Sujeet Jha,Norihiro Kato,Vittorio Krogh,Michael Laffan,Christa Meisinger,Thomas Meitinger,Zuan Yu Mok,Valeria Motta,Hong Kiat Ng,Zacharoula Nikolakopoulou,Georgios Nteliopoulos,Salvatore Panico,Natalia Pervjakova,Holger Prokisch,Wolfgang Rathmann,Michael Roden,Federica Rota,Michelle Ann Rozario,Johanna K. Sandling,Johanna K. Sandling,Clemens Schafmayer,Katharina Schramm,Reiner Siebert,Reiner Siebert,P. Eline Slagboom,Pasi Soininen,Pasi Soininen,Lisette Stolk,Konstantin Strauch,E-Shyong Tai,Letizia Tarantini,Barbara Thorand,Ettje F. Tigchelaar,Rosario Tumino,André G. Uitterlinden,Cornelia M. van Duijn,Joyce B. J. van Meurs,Paolo Vineis,Ananda R. Wickremasinghe,Cisca Wijmenga,Tsun-Po Yang,Wei Yuan,Wei Yuan,Alexandra Zhernakova,Rachel L. Batterham,George Davey Smith,Panos Deloukas,Panos Deloukas,Panos Deloukas,Bastiaan T. Heijmans,Christian Herder,Albert Hofman,Cecilia M. Lindgren,Cecilia M. Lindgren,Lili Milani,Pim van der Harst,Annette Peters,Thomas Illig,Caroline L Relton,Melanie Waldenberger,Marjo-Riitta Järvelin,Valentina Bollati,Richie Soong,Tim D. Spector,James Scott,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Paul Elliott,Paul Elliott,Jordana T. Bell,Giuseppe Matullo,Christian Gieger,Jaspal S. Kooner,Harald Grallert,John C. Chambers +123 more
TL;DR: In this article, the authors used epigenome-wide association to show that body mass index (BMI), a key measure of adiposity, is associated with widespread changes in DNA methylation.
Journal ArticleDOI
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
Albert Tenesa,Susan M. Farrington,James G. D. Prendergast,Mary Porteous,Marion F Walker,Naila Haq,Rebecca A. Barnetson,Evropi Theodoratou,Roseanne Cetnarskyj,Nicola Cartwright,Colin A. Semple,Andrew G. Clark,Fiona Reid,Lorna Smith,Kostas Kavoussanakis,Thibaud Koessler,Paul D.P. Pharoah,Stephan Buch,Clemens Schafmayer,Jürgen Tepel,Stefan Schreiber,Henry Völzke,Carsten Oliver Schmidt,Jochen Hampe,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Stefan Wilkening,Federico Canzian,Gabriel Capellá,Victor Moreno,Ian J. Deary,John M. Starr,Ian Tomlinson,Zoe Kemp,Kimberley Howarth,Luis G. Carvajal-Carmona,Emily L. Webb,Peter Broderick,Jayaram Vijayakrishnan,Richard S. Houlston,Gad Rennert,Dennis G. Ballinger,Laura S. Rozek,Stephen B. Gruber,Koichi Matsuda,Tomohide Kidokoro,Yusuke Nakamura,Brent W. Zanke,Brent W. Zanke,Brent W. Zanke,Celia M. T. Greenwood,Celia M. T. Greenwood,Jagadish Rangrej,Jagadish Rangrej,Rafal Kustra,Alexandre Montpetit,Thomas J. Hudson,Thomas J. Hudson,Steven Gallinger,Steven Gallinger,Harry Campbell,Malcolm G. Dunlop +62 more
TL;DR: Findings extend the understanding of the role of common genetic variation in CRC etiology by identifying a previously unreported association, rs3802842 on 11q23, and carrying all six possible risk alleles yielded OR = 2.6 (95% CI = 1.75–3.89) for CRC.
Journal ArticleDOI
Obesity accelerates epigenetic aging of human liver
Steve Horvath,Wiebke Erhart,Mario Brosch,Ole Ammerpohl,Witigo von Schönfels,M Ahrens,Nils Heits,Jordana T. Bell,Pei-Chien Tsai,Tim D. Spector,Panos Deloukas,Reiner Siebert,Bence Sipos,Thomas Becker,Christoph Röcken,Clemens Schafmayer,Jochen Hampe +16 more
TL;DR: The epigenetic age acceleration, which is not reversible in the short term after rapid weight loss induced by bariatric surgery, may play a role in liver-related comorbidities of obesity, such as insulin resistance and liver cancer.
Journal ArticleDOI
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
Richard S. Houlston,Emily L. Webb,Peter Broderick,Alan M. Pittman,Maria Chiara Di Bernardo,Steven J. Lubbe,Ian Chandler,Jayaram Vijayakrishnan,Kate Sullivan,Steven Penegar,Luis G. Carvajal-Carmona,Kimberley Howarth,Emma Jaeger,Sarah L. Spain,Axel Walther,Ella Barclay,Lynn Martin,Maggie Gorman,Enric Domingo,Ana Teixeira,David J. Kerr,Jean-Baptiste Cazier,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Ian Tomlinson,Susan M. Farrington,Albert Tenesa,James Prendergast,Rebecca A. Barnetson,Roseanne Cetnarskyj,Mary Porteous,Paul D.P. Pharoah,Thibaud Koessler,Jochen Hampe,Stephan Buch,Clemens Schafmayer,Jürgen Tepel,Stefan Schreiber,Henry Völzke,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Brent W. Zanke,Alexandre Montpetit,Thomas J. Hudson,Thomas J. Hudson,Thomas J. Hudson,Steven Gallinger,Steven Gallinger,Harry Campbell,Malcolm G. Dunlop +52 more
TL;DR: Four previously unreported CRC risk loci are identified at 14q22.2, highlighting the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC.
Journal ArticleDOI
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Ian Tomlinson,Emily L. Webb,Luis G. Carvajal-Carmona,Peter Broderick,Kimberley Howarth,Alan M. Pittman,Sarah L. Spain,Steven J. Lubbe,Axel Walther,Kate Sullivan,Emma Jaeger,Sarah Fielding,Andrew Rowan,Jayaram Vijayakrishnan,Enric Domingo,Ian Chandler,Zoe Kemp,Mobshra Qureshi,Susan M. Farrington,Albert Tenesa,James G. D. Prendergast,Rebecca A. Barnetson,Steven Penegar,Ella Barclay,Wendy Wood,Lynn Martin,Lynn Martin,Lynn Martin,Maggie Gorman,Huw Thomas,Julian Peto,D. Timothy Bishop,Richard Gray,Eamonn R. Maher,Anneke Lucassen,David J. Kerr,D. Gareth Evans,Clemens Schafmayer,Stephan Buch,Henry Völzke,Jochen Hampe,Stefan Schreiber,Ulrich John,Thibaud Koessler,Paul D.P. Pharoah,Tom van Wezel,Hans Morreau,Juul T. Wijnen,John L. Hopper,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Gianluca Severi,Sergi Castellví-Bel,Clara Ruiz-Ponte,Angel Carracedo,Antoni Castells,Asta Försti,Asta Försti,Kari Hemminki,Kari Hemminki,Pavel Vodicka,Alessio Naccarati,Lara Lipton,Judy W. C. Ho,King Yip Cheng,Pak C. Sham,John M. Luk,José A. G. Agúndez,José M. Ladero,Miguel de la Hoya,Trinidad Caldés,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Jean-Baptiste Cazier,Harry Campbell,Malcolm G. Dunlop,Richard S. Houlston +79 more
TL;DR: Genetic data provide further evidence for the 'common-disease common-variant' model of CRC predisposition and identify two previously unreported associations.