Tingting Jiang

TL;DR: The predictive and modeling capabilities of DeepSurv will enable medical researchers to use deep neural networks as a tool in their exploration, understanding, and prediction of the effects of a patient’s characteristics on their risk of failure.

TL;DR: DeepSurv as discussed by the authors is a Cox proportional hazards deep neural network and state-of-the-art survival method for modeling interactions between a patient's covariates and treatment effectiveness in order to provide personalized treatment recommendations.

TL;DR: Regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 by the ubiquitin ligase RNF5 underlies BCa response to chemotherapies and indicates positive prognosis in BCa.

TL;DR: High immune gene expression and lower clonal heterogeneity in TNBC and HER2+ cancers suggest an immune pruning effect and equilibrium between immune surveillance and clonal expansion, and immune checkpoint inhibitors may tip the balance in favor of immune surveillance in these cancers.

TL;DR: This study suggests that immune-rich TNBCs may be under an immune surveillance that continuously eliminates many immunogenic clones, resulting in lower clonal heterogeneity and may also represent the subset of T NBCs that could derive benefit from immune checkpoint inhibitor therapy to tilt the balance in favor of the immune system.