T
Tobias Fromme
Researcher at Technische Universität München
Publications - 64
Citations - 2472
Tobias Fromme is an academic researcher from Technische Universität München. The author has contributed to research in topics: Brown adipose tissue & Thermogenin. The author has an hindex of 23, co-authored 57 publications receiving 2017 citations. Previous affiliations of Tobias Fromme include Ludwig Maximilian University of Munich & University of Marburg.
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Journal ArticleDOI
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups
André Scherag,Christian Dina,Anke Hinney,Vincent Vatin,Susann Scherag,Carla I. G. Vogel,Timo D. Müller,Timo D. Müller,Harald Grallert,H.-Erich Wichmann,Beverley Balkau,Barbara Heude,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Anna-Liisa Hartikainen,Claire Levy-Marchal,Jacques Weill,Jérôme Delplanque,Antje Körner,Wieland Kiess,Peter Kovacs,Nigel W. Rayner,Nigel W. Rayner,Inga Prokopenko,Inga Prokopenko,Mark I. McCarthy,Mark I. McCarthy,Helmut Schäfer,Ivonne Jarick,Heiner Boeing,Eva Fisher,Thomas Reinehr,Joachim Heinrich,Peter Rzehak,Dietrich Berdel,Michael Borte,Michael Borte,Heike Biebermann,Heiko Krude,Dieter Rosskopf,Christian Rimmbach,Winfried Rief,Tobias Fromme,Martin Klingenspor,Annette Schürmann,Nadja Schulz,Markus M. Nöthen,Thomas W. Mühleisen,Raimund Erbel,Karl-Heinz Jöckel,Susanne Moebus,Tanja Boes,Thomas Illig,Philippe Froguel,Philippe Froguel,Johannes Hebebrand,David Meyre +56 more
TL;DR: It is observed that genetic variants in or near FTO, MC4R, TMEM18, SDCCAG8, and TNKS/MSRA were robustly associated with early-onset obesity and major common variants related to obesity overlap to a substantial degree between children and adults.
Journal ArticleDOI
Proteome Differences between Brown and White Fat Mitochondria Reveal Specialized Metabolic Functions
Francesca Forner,Chanchal Kumar,Christian A. Luber,Tobias Fromme,Martin Klingenspor,Matthias Mann +5 more
TL;DR: High-resolution quantitative mass spectrometry is applied to directly and accurately compare the in vivo mouse mitochondrial proteomes of brown and white adipocytes to directly address functional questions in metabolism.
Journal ArticleDOI
Uncoupling protein 1 expression and high-fat diets.
Tobias Fromme,Martin Klingenspor +1 more
TL;DR: The general impression from an overview of the present literature is an increased brown adipose tissue Ucp1 mRNA and protein content after feeding a high-fat diet (HFD) to mice and rats.
Journal ArticleDOI
Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation.
Yongguo Li,Katharina Schnabl,Sarah-Madeleine Gabler,Monja Willershäuser,Josefine Reber,Angelos Karlas,Sanna Laurila,Minna Lahesmaa,Mueez U Din,Andrea Bast-Habersbrunner,Kirsi A. Virtanen,Tobias Fromme,Florian Bolze,Libbey S. O’Farrell,Jorge Alsina-Fernandez,Tamer Coskun,Vasilis Ntziachristos,Pirjo Nuutila,Pirjo Nuutila,Martin Klingenspor +19 more
TL;DR: The gut hormone secretin is identified as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequentially induces satiation, thereby establishing a gut-secretin-BAT-brain axis in mammals with a physiological role of prandials thermogenesis in the control of satiation.
Journal ArticleDOI
Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice.
Carola W. Meyer,Monja Willershäuser,Martin Jastroch,Bryan C. Rourke,Tobias Fromme,Rebecca Oelkrug,Gerhard Heldmaier,Martin Klingenspor +7 more
TL;DR: It is concluded that BAT is required for maximal adaptive thermogenesis but also allows metabolic flexibility and a rapid switch toward sustained lipid-fuelled thermogenesis as an acute response to cold.