C
Christian Dina
Researcher at Centre national de la recherche scientifique
Publications - 29
Citations - 11068
Christian Dina is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 22, co-authored 29 publications receiving 10522 citations. Previous affiliations of Christian Dina include University of Nantes & Pasteur Institute.
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Journal ArticleDOI
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek,Ghislain Rocheleau,Johan Rung,Christian Dina,Lishuang Shen,David Serre,Philippe Boutin,Daniel Vincent,Alexandre Belisle,Samy Hadjadj,Beverley Balkau,Barbara Heude,Guillaume Charpentier,Thomas J. Hudson,Thomas J. Hudson,Alexandre Montpetit,Alexey V. Pshezhetsky,Marc Prentki,Barry I. Posner,David J. Balding,David Meyre,Constantin Polychronakos,Philippe Froguel,Philippe Froguel +23 more
TL;DR: Four loci containing variants that confer type 2 diabetes risk are identified and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits.
Journal ArticleDOI
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Josée Dupuis,Josée Dupuis,Claudia Langenberg,Inga Prokopenko,Richa Saxena,Richa Saxena,Nicole Soranzo,Nicole Soranzo,Anne U. Jackson,Eleanor Wheeler,Nicole L. Glazer,Nabila Bouatia-Naji,Anna L. Gloyn,Cecilia M. Lindgren,Reedik Mägi,Andrew P. Morris,Joshua C. Randall,Toby Johnson,Toby Johnson,Paul Elliott,Paul Elliott,Denis Rybin,Gudmar Thorleifsson,Valgerdur Steinthorsdottir,Peter Henneman,Harald Grallert,Abbas Dehghan,Jouke JanHottenga,Christopher S. Franklin,Pau Navarro,Kijoung Song,Anuj Goel,John R. B. Perry,Josephine M. Egan,Taina K. Lajunen,Niels Grarup,Thomas Sparsø,Alex S. F. Doney,Benjamin F. Voight,Benjamin F. Voight,Heather M. Stringham,Man Li,Stavroula Kanoni,Peter Shrader,Christine Cavalcanti-Proença,Meena Kumari,Lu Qi,Nicholas J. Timpson,Christian Gieger,Carina Zabena,Ghislain Rocheleau,Erik Ingelsson,Erik Ingelsson,Ping An,Jeffrey R. O'Connell,Jian'an Luan,Amanda F. Elliott,Amanda F. Elliott,Steven A. McCarroll,Steven A. McCarroll,Felicity Payne,Rosa Maria Roccasecca,François Pattou,Praveen Sethupathy,Kristin Ardlie,Yavuz Ariyurek,Beverley Balkau,Philip J. Barter,John Beilby,Yoav Ben-Shlomo,Rafn Benediktsson,Amanda J. Bennett,Sven Bergmann,Sven Bergmann,Murielle Bochud,Eric Boerwinkle,Amélie Bonnefond,Lori L. Bonnycastle,Knut Borch-Johnsen,Knut Borch-Johnsen,Yvonne Böttcher,Eric J. Brunner,Suzannah Bumpstead,Guillaume Charpentier,Yii Der IdaChen,Peter S. Chines,Robert Clarke,Lachlan J. McOin,Mark E. Cooper,Marilyn C. Cornelis,Gabe Crawford,Laura Crisponi,Ian N. M. Day,Eco J. C. de Geus,Jérôme Delplanque,Christian Dina,Michael R. Erdos,A C Fedson,Antje Fischer-Rosinsky,Nita G. Forouhi,Caroline S. Fox,Caroline S. Fox,Rune R. Frants,Maria GraziaFranzosi,Pilar Galan,Mark O. Goodarzi,J. Graessler,Christopher J. Groves,Scott M. Grundy,Rhian Gwilliam,Ulf Gyllensten,Samy Hadjadj,Göran Hallmans,Naomi Hammond,Xijing Han,Anna LiisaHartikainen,Neelam Hassanali,Caroline Hayward,Simon Heath,Serge Hercberg,Christian Herder,Andrew A. Hicks,David R. Hillman,Aroon D. Hingorani,Albert Hofman,Jennie Hui,Joseph Hung,Joseph Hung,Bo Isomaa,Paul Johnson,Torben Jørgensen,Antti Jula,Marika Kaakinen,Jaakko Kaprio,Jaakko Kaprio,Y. AnteroKesaniemi,Mika Kivimäki,Beatrice Knight,Seppo Koskinen,Peter Kovacs,Kirsten Ohm Kyvik,G. Mark Lathrop,Debbie A Lawlor,Olivier Le Bacquer,Cécile Lecoeur,Yun Li,Valeriya Lyssenko,Robert W. Mahley,Massimo Mangino,Alisa K. Manning,María TeresaMartínez-Larrad,Jarred B. McAteer,Jarred B. McAteer,Laura J. McCulloch,Ruth McPherson,Christa Meisinger,David Melzer,David Meyre,Braxton D. Mitchell,Mario A. Morken,Sutapa Mukherjee,Silvia Naitza,Narisu Narisu,Matt Neville,Ben A. Oostra,Marco Orrù,Ruth E. Pakyz,Colin N. Apalmer,Giuseppe Paolisso,Cristian Pattaro,Daniel S. Pearson,John F. Peden,Nancy L. Pedersen,Markus Perola,Markus Perola,Andreas Pfeiffer,Irene Pichler,Ozren Polasek,Danielle Posthuma,Simon C. Potter,Anneli Pouta,Michael A. Province,Bruce M. Psaty,Bruce M. Psaty,Wolfgang Rathmann,Nigel W. Rayner,Kenneth Rice,Samuli Ripatti,Samuli Ripatti,Fernando Rivadeneira,Michael Roden,Olov Rolandsson,Annelli Sandbæk,Manjinder S. Sandhu,Serena Sanna,Avan Aihie Sayer,Paul Scheet,Laura J. Scott,Udo Seedorf,Stephen J. Sharp,Beverley M. Shields,Gunnar Sigursson,Eric J.G. Sijbrands,Angela Silveira,Laila Simpson,Andrew B. Singleton,Nicholas L. Smith,Nicholas L. Smith,Ulla Sovio,Amy J. Swift,Holly E. Syddall,Ann ChristineSyvänen,Toshiko Tanaka,Toshiko Tanaka,Barbara Thorand,Jean Tichet,Anke Tönjes,Tiinamaija Tuomi,André G. Uitterlinden,Ko Willems van Dijk,Mandy van Hoek,Dhiraj Varma,Sophie Visvikis-Siest,Veronique Vitart,Nicole Vogelzangs,Gerard Waeber,Peter Wagner,Peter Wagner,Andrew Walley,G. BragiWalters,Kim L. Ward,Hugh Watkins,Michael N. Weedon,Sarah H. Wild,Gonneke Willemsen,Jaqueline C. MWitteman,John W. GYarnell,Eleftheria Zeggini,Eleftheria Zeggini,Diana Zelenika,Björn Zethelius,Björn Zethelius,Guangju Zhai,Jing Hua Zhao,M. Carola Zillikens,Ingrid B. Borecki,Ruth J. F. Loos,Pierre Meneton,Patrik K. E. Magnusson,David M. Nathan,Gordon H. Williams,Andrew T. Hattersley,Kaisa Silander,Kaisa Silander,Veikko Salomaa,George Davey Smith,Stefan R. Bornstein,Peter Schwarz,Joachim Spranger,Fredrik Karpe,Alan R. Shuldiner,Cyrus Cooper,George Dedoussis,Manuel Serrano-Ríos,Andrew D. Morris,Lars Lind,Lyle J. Palmer,Lyle J. Palmer,Frank B. Hu,Paul W. Franks,Shah Ebrahim,Michael Marmot,W. H. Linda Kao,James S. Pankow,Mike Sampson,Johanna Kuusisto,Markku Laakso,Torben Hansen,Torben Hansen,Oluf Pedersen,Oluf Pedersen,Oluf Pedersen,Peter P. Pramstaller,H.-Erich Wichmann,Thomas Illig,Igor Rudan,Igor Rudan,Alan F. Wright,Michael Stumvoll,Harry Campbell,James F. Wilson,Richard N. Bergman,Thomas A. Buchanan,Francis S. Collins,Karen L. Mohlke,Jaakko Tuomilehto,Jaakko Tuomilehto,Timo T. Valle,David Altshuler,David Altshuler,Jerome I. Rotter,David S. Siscovick,Brenda W.J.H. Penninx,Dorret I. Boomsma,Panos Deloukas,Tim D. Spector,Tim D. Spector,Timothy M. Frayling,Luigi Ferrucci,Augustine Kong,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Cornelia M. van Duijn,Yurii S. Aulchenko,Antonio Cao,Angelo Scuteri,David Schlessinger,Manuela Uda,Aimo Ruokonen,Marjo Riitta-Järvelin,Marjo Riitta-Järvelin,Dawn M. Waterworth,Peter Vollenweider,Leena Peltonen,Vincent Mooser,Gonçalo R. Abecasis,Nicholas J. Wareham,Robert Sladek,Philippe Froguel,Philippe Froguel,Richard M. Watanabe,James B. Meigs,Leif Groop,Michael Boehnke,Mark I. McCarthy,Jose C. Florez,Jose C. Florez,Inês Barroso +339 more
TL;DR: It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
Journal ArticleDOI
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Benjamin F. Voight,Benjamin F. Voight,Laura J. Scott,Valgerdur Steinthorsdottir,Andrew P. Morris,Christian Dina,Christian Dina,Ryan P. Welch,Eleftheria Zeggini,Eleftheria Zeggini,Cornelia Huth,Yurii S. Aulchenko,Gudmar Thorleifsson,Laura J. McCulloch,Teresa Ferreira,Harald Grallert,Najaf Amin,Guanming Wu,Cristen J. Willer,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,Steve McCarroll,Steve McCarroll,Claudia Langenberg,Oliver Hofmann,Josée Dupuis,Lu Qi,Lu Qi,Ayellet V. Segrè,Ayellet V. Segrè,Mandy van Hoek,Pau Navarro,Kristin Ardlie,Beverley Balkau,Rafn Benediktsson,Amanda J. Bennett,Roza Blagieva,Eric Boerwinkle,Lori L. Bonnycastle,Kristina Bengtsson Boström,Bert Bravenboer,Suzannah Bumpstead,N P Burtt,Guillaume Charpentier,Peter S. Chines,Marilyn C. Cornelis,David Couper,Gabe Crawford,Alex S. F. Doney,Katherine S. Elliott,Amanda F. Elliott,Amanda F. Elliott,Michael R. Erdos,Caroline S. Fox,Christopher S. Franklin,Martha Ganser,Christian Gieger,Niels Grarup,Todd Green,Todd Green,Simon J. Griffin,Christopher J. Groves,Candace Guiducci,Samy Hadjadj,Neelam Hassanali,Christian Herder,Bo Isomaa,Anne U. Jackson,Paul Johnson,Torben Jørgensen,Torben Jørgensen,Wen H. L. Kao,Norman Klopp,Augustine Kong,Peter Kraft,Johanna Kuusisto,Torsten Lauritzen,Man Li,Aloysius G Lieverse,Cecilia M. Lindgren,Valeriya Lyssenko,Michel Marre,Michel Marre,Thomas Meitinger,Kristian Midthjell,Mario A. Morken,Narisu Narisu,Peter M. Nilsson,Katharine R. Owen,Felicity Payne,John R. B. Perry,Ann-Kristin Petersen,Carl G. P. Platou,Christine Proença,Inga Prokopenko,Inga Prokopenko,Wolfgang Rathmann,N. William Rayner,N. William Rayner,Neil R. Robertson,Neil R. Robertson,Ghislain Rocheleau,Michael Roden,Mike Sampson,Richa Saxena,Richa Saxena,Beverley M. Shields,Peter Shrader,Gunnar Sigurdsson,Thomas Sparsø,Klaus Strassburger,Heather M. Stringham,Qi Sun,Amy J. Swift,Barbara Thorand,Jean Tichet,Tiinamaija Tuomi,Rob M. van Dam,Timon W. van Haeften,Thijs T. W. van Herpt,Jana V. van Vliet-Ostaptchouk,G. Bragi Walters,Michael N. Weedon,Cisca Wijmenga,Jacqueline C. M. Witteman,Richard N. Bergman,Stéphane Cauchi,Francis S. Collins,Anna L. Gloyn,Ulf Gyllensten,Torben Hansen,Winston Hide,Graham A. Hitman,Albert Hofman,David J. Hunter,Kristian Hveem,Markku Laakso,Karen L. Mohlke,Andrew D. Morris,Colin N. A. Palmer,Peter P. Pramstaller,Igor Rudan,Igor Rudan,Eric J.G. Sijbrands,Lincoln Stein,Jaakko Tuomilehto,Jaakko Tuomilehto,André G. Uitterlinden,Mark Walker,Nicholas J. Wareham,Richard M. Watanabe,Gonçalo R. Abecasis,Bernhard O. Boehm,Harry Campbell,Mark J. Daly,Mark J. Daly,Andrew T. Hattersley,Frank B. Hu,Frank B. Hu,James B. Meigs,James S. Pankow,Oluf Pedersen,H-Erich Wichmann,Inês Barroso,Jose C. Florez,Timothy M. Frayling,Leif Groop,Leif Groop,Robert Sladek,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,James F. Wilson,Thomas Illig,Philippe Froguel,Philippe Froguel,Cornelia M. van Duijn,Kari Stefansson,Kari Stefansson,David Altshuler,Michael Boehnke,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy +183 more
TL;DR: By combining genome-wide association data from 8,130 individuals with type 2 diabetes and 38,987 controls of European descent and following up previously unidentified meta-analysis signals, 12 new T2D association signals are identified with combined P < 5 × 10−8.
Journal ArticleDOI
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Richa Saxena,Richa Saxena,Claudia Langenberg,Toshiko Tanaka,Toshiko Tanaka,James S. Pankow,Peter Vollenweider,Valeriya Lyssenko,Nabila Bouatia-Naji,Josée Dupuis,Anne U. Jackson,W. H. Linda Kao,Man Li,Nicole L. Glazer,Alisa K. Manning,Jian Anluan,Heather M. Stringham,Inga Prokopenko,Toby Johnson,Niels Grarup,Trine Welløv Boesgaard,Cécile Lecoeur,Peter Shrader,Jeffrey R. O'Connell,Erik Ingelsson,Erik Ingelsson,David Couper,Kenneth Rice,Kijoung Song,Camilla H. Andreasen,Christian Dina,Anna Köttgen,Olivier Le Bacquer,François Pattou,Jalal Taneera,Valgerdur Steinthorsdottir,Denis Rybin,Kristin Ardlie,Mike Sampson,Lu Qi,Mandy van Hoek,Michael N. Weedon,Yurii S. Aulchenko,Benjamin F. Voight,Benjamin F. Voight,Harald Grallert,Beverley Balkau,Richard N. Bergman,Suzette J. Bielinski,Amélie Bonnefond,Lori L. Bonnycastle,Knut Borch-Johnsen,Yvonne Böttcher,Eric J. Brunner,Thomas A. Buchanan,Suzannah Bumpstead,Christine Cavalcanti-Proença,Guillaume Charpentier,Yii-Der Ida Chen,Peter S. Chines,Francis S. Collins,Marilyn C. Cornelis,Gabriel Crawford,Jérôme Delplanque,Alex S. F. Doney,Josephine M. Egan,Michael R. Erdos,Mathieu Firmann,Nita G. Forouhi,Caroline S. Fox,Caroline S. Fox,Mark O. Goodarzi,J. Graessler,Aroon D. Hingorani,Bo Isomaa,Torben Jørgensen,Mika Kivimäki,Peter Kovacs,Knut Krohn,Meena Kumari,Torsten Lauritzen,Claire Levy-Marchal,Vladimir Mayor,Jarred B. McAteer,Jarred B. McAteer,David Meyre,Braxton D. Mitchell,Karen L. Mohlke,Mario A. Morken,Narisu Narisu,Colin N. Apalmer,Ruth E. Pakyz,Laura Pascoe,Felicity Payne,Daniel S. Pearson,Wolfgang Rathmann,Annelli Sandbæk,Avan Aihie Sayer,Laura J. Scott,Stephen J. Sharp,Eric J.G. Sijbrands,Andrew B. Singleton,David S. Siscovick,Nicholas L. Smith,Nicholas L. Smith,Thomas Sparsø,Amy J. Swift,Holly E. Syddall,Gudmar Thorleifsson,Anke Tönjes,Anke Tönjes,Tiinamaija Tuomi,Jaakko Tuomilehto,Valle Tt,Gerard Waeber,Andrew Walley,Dawn M. Waterworth,Eleftheria Zeggini,Jing Hua Zhao,Thomas Illig,H.-Erich Wichmann,H.-Erich Wichmann,James F. Wilson,Cornelia M. van Duijn,Frank B. Hu,Frank B. Hu,Andrew D. Morris,Timothy M. Frayling,Timothy M. Frayling,Andrew T. Hattersley,Andrew T. Hattersley,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Peter M. Nilsson,Ann-Christine Syvänen,Alan R. Shuldiner,Alan R. Shuldiner,Mark Walker,Stefan R. Bornstein,Peter Schwarz,Gordon H. Williams,David M. Nathan,Johanna Kuusisto,Markku Laakso,Cyrus Cooper,Michael Marmot,Luigi Ferrucci,Vincent Mooser,Michael Stumvoll,Ruth J. F. Loos,David Altshuler,David Altshuler,Bruce M. Psaty,Jerome I. Rotter,Eric Boerwinkle,Torben Hansen,Torben Hansen,Oluf Pedersen,Oluf Pedersen,Jose C. Florez,Jose C. Florez,Mark I. McCarthy,Mark I. McCarthy,Michael Boehnke,Inês Barroso,Robert Sladek,Philippe Froguel,Philippe Froguel,James B. Meigs,Leif Groop,Nicholas J. Wareham,Richard M. Watanabe +173 more
TL;DR: A meta-analysis of nine genome-wide association studies and a follow-up of 29 independent loci found three newly implicated loci to be associated with type 2 diabetes: GIPR, ADCY5 and VPS13C.
Journal ArticleDOI
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
Nabila Bouatia-Naji,Amélie Bonnefond,Amélie Bonnefond,Christine Cavalcanti-Proença,Christine Cavalcanti-Proença,Thomas Sparsø,Johan Holmkvist,Marion Marchand,Marion Marchand,Jérôme Delplanque,Jérôme Delplanque,Stéphane Lobbens,Stéphane Lobbens,Ghislain Rocheleau,Emmanuelle Durand,Emmanuelle Durand,Franck De Graeve,Franck De Graeve,Jean-Claude Chèvre,Jean-Claude Chèvre,Knut Borch-Johnsen,Anna-Liisa Hartikainen,Aimo Ruokonen,Jean Tichet,Michel Marre,Michel Marre,Jacques Weill,Barbara Heude,Barbara Heude,Maithé Tauber,Katleen Lemaire,Frans Schuit,Paul Elliott,Torben Jørgensen,Guillaume Charpentier,Samy Hadjadj,Stéphane Cauchi,Stéphane Cauchi,Martine Vaxillaire,Martine Vaxillaire,Robert Sladek,Sophie Visvikis-Siest,Beverley Balkau,Beverley Balkau,Claire Levy-Marchal,Claire Levy-Marchal,François Pattou,David Meyre,David Meyre,Alexandra I. F. Blakemore,M. R. Järvelin,M. R. Järvelin,Andrew Walley,Torben Hansen,Christian Dina,Christian Dina,Oluf Pedersen,Oluf Pedersen,Philippe Froguel,Philippe Froguel,Philippe Froguel +60 more
TL;DR: The data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway and show MT2 expression in human pancreatic islets and beta cells.