T
Toby J. Gibson
Researcher at European Bioinformatics Institute
Publications - 176
Citations - 177834
Toby J. Gibson is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Short linear motif & Eukaryotic Linear Motif resource. The author has an hindex of 78, co-authored 171 publications receiving 167371 citations. Previous affiliations of Toby J. Gibson include University of Rome Tor Vergata & University College Dublin.
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Journal ArticleDOI
Proteome-wide analysis of human disease mutations in short linear motifs: neglected players in cancer?
Bora Uyar,Robert J. Weatheritt,Robert J. Weatheritt,Holger Dinkel,Norman E. Davey,Toby J. Gibson +5 more
TL;DR: In this article, a proteome-wide comparison of the distribution of missense mutations from disease and non-disease mutation datasets revealed that, in IDRs, disease mutations are more likely to occur within SLiMs than neutral missense mutants.
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CTCF-Mediated Chromatin Loops between Promoter and Gene Body Regulate Alternative Splicing across Individuals
Mariana Ruiz-Velasco,Manjeet Kumar,Mang Ching Lai,Pooja Bhat,Ana Belen Solis-Pinson,Alejandro Reyes,Stefan Kleinsorg,Kyung-Min Noh,Toby J. Gibson,Judith B. Zaugg +9 more
TL;DR: This study suggests that alternative exon usage is regulated by CTCF-dependent chromatin structure and is likely to downregulate enzyme activity by disrupting annotated protein domains.
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The Eukaryotic Linear Motif resource: 2022 release
Manjeet Kumar,Sushama Michael,Jesús Alvarado-Valverde,Bálint Mészáros,Hugo Sámano-Sánchez,Hugo Sámano-Sánchez,András Zeke,László Dobson,Tamas Lazar,Tamas Lazar,Mihkel Örd,Anurag Nagpal,Nazanin Farahi,Nazanin Farahi,Melanie Käser,Ramya Kraleti,Norman E. Davey,Rita Pancsa,Lucía B. Chemes,Toby J. Gibson +19 more
TL;DR: The Eukaryotic Linear Motif (ELM) as discussed by the authors provides a comprehensive, regularly updated and well-organised repository of manually curated, experimentally validated short linear motifs (SLiMs).
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Solution structure of the basic region from the transcriptional activator GCN4.
TL;DR: The structure of the basic region (i.e., the region responsible for sequence-specific binding to DNA) of the transcriptional activator GCN4 was studied and possible consequences for the binding toDNA are discussed.
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Structure of murine complement component C3. II. Nucleotide sequence of cloned complementary DNA coding for the alpha chain.
TL;DR: This study completes the nucleotide and amino acid structure of the murine precursor prepro-C3 molecule and predicts two possible carbohydrate attachment sites in the human C3 alpha chain.