T
Toby J. Gibson
Researcher at European Bioinformatics Institute
Publications - 176
Citations - 177834
Toby J. Gibson is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Short linear motif & Eukaryotic Linear Motif resource. The author has an hindex of 78, co-authored 171 publications receiving 167371 citations. Previous affiliations of Toby J. Gibson include University of Rome Tor Vergata & University College Dublin.
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Journal ArticleDOI
A regular pattern of two types of 100-residue motif in the sequence of titin.
Siegfried Labeit,Denise P. Barlow,Mathias Gautel,Toby J. Gibson,J. Holt,Chih-Lin Hsieh,Uta Francke,Kevin Leonard,J Wardale,A. Whiting,John Trinick +10 more
TL;DR: It is shown that partial titin complementary DNAs encode a regular pattern of two types of 100-residue motif, each of which probably folds into a separate domain type.
Journal ArticleDOI
ELM-the eukaryotic linear motif resource in 2020.
Manjeet Kumar,Marc Gouw,Sushama Michael,Hugo Sámano-Sánchez,Rita Pancsa,Juliana Glavina,Athina Diakogianni,Jesús Alvarado Valverde,Dayana Bukirova,Jelena Čalyševa,Nicolas Palopoli,Norman E. Davey,Lucía B. Chemes,Toby J. Gibson +13 more
TL;DR: The eukaryotic linear motif resource is a repository of manually curated experimentally validated short linear motifs (SLiMs) and the current release of the ELM database contains 289 motif classes and 3523 individual protein motif instances manually curated from 3467 scientific publications.
Journal ArticleDOI
Malectin – A Novel Carbohydrate-binding Protein of the Endoplasmic Reticulum and a Candidate Player in the Early Steps of Protein N-glycosylation
Thomas Schallus,Christine Jaeckh,Krisztina Fehér,Angelina S. Palma,Yan Liu,Jeremy C. Simpson,Muhammad Mukram Mohamed Mackeen,Gunter Stier,Toby J. Gibson,Ten Feizi,Tomas Pieler,Claudia Muhle-Goll +11 more
TL;DR: The localization, structure, and binding specificity of this protein, which is named malectin, open the way to studies of its role in the genesis, processing and secretion of N-glycosylated proteins.
Journal ArticleDOI
The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation.
Matthew J. Bottomley,Michael W. Collard,Jodi I. Huggenvik,Zhihong Liu,Toby J. Gibson,Michael Sattler +5 more
TL;DR: The three-dimensional structure of the SAND domain from Sp100b represents a novel α/β fold, in which a conserved KDWK sequence motif is found within an α-helical, positively charged surface patch.
Journal ArticleDOI
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
Karsten Boldt,van Reeuwijk J,Lu Q,Konstantinos Koutroumpas,Nguyen Tm,Yves Texier,Yves Texier,van Beersum Se,Nicola Horn,Willer,Dorus A. Mans,Gerard W. Dougherty,Ideke J.C. Lamers,Karlien L.M. Coene,Heleen H. Arts,Matthew J. Betts,Beyer T,Emine Bolat,Christian Johannes Gloeckner,Haidari K,Lisette Hetterschijt,Daniela Iaconis,Jenkins D,Franziska Klose,Barbara Knapp,Brooke L. Latour,Stef J.F. Letteboer,Carlo Marcelis,Mitic D,Manuela Morleo,Machteld M. Oud,Moniek Riemersma,Suzanne Rix,Paulien A Terhal,Grischa Toedt,van Dam Tj,de Vrieze E,Yasmin Wissinger,Wu Km,Gordana Apic,PL Beales,Oliver E. Blacque,Toby J. Gibson,Martijn A. Huynen,Nicholas Katsanis,Hannie Kremer,Heymut Omran,van Wijk E,Uwe Wolfrum,François Képès,Erica E. Davis,Brunella Franco,Rachel H. Giles,Marius Ueffing,Robert B. Russell,Ronald Roepman +55 more
TL;DR: It is shown that 3M genes are involved in ciliogenesis, and that patient fibroblasts lack cilia, and the landscape suggests other genetic diseases could be ciliary including 3M syndrome.