T
Tom J. H. Ruigrok
Researcher at Erasmus University Rotterdam
Publications - 90
Citations - 6972
Tom J. H. Ruigrok is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Cerebellum & Cerebellar cortex. The author has an hindex of 43, co-authored 86 publications receiving 6359 citations.
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Journal ArticleDOI
Microcircuitry and function of the inferior olive
C. I. De Zeeuw,John Simpson,Casper C. Hoogenraad,Niels Galjart,Sebastiaan K. E. Koekkoek,Tom J. H. Ruigrok +5 more
TL;DR: It is proposed that the microcircuitry of the inferior olive is capable of functioning both in motor learning and motor timing, but does not directly compare intended with achieved movements.
Journal ArticleDOI
Deletion of FMR1 in Purkinje Cells Enhances Parallel Fiber LTD, Enlarges Spines, and Attenuates Cerebellar Eyelid Conditioning in Fragile X Syndrome
Sebastiaan K. E. Koekkoek,K. Yamaguchi,B.A. Milojkovic,Bjorn R. Dortland,Tom J. H. Ruigrok,Reinoud Maex,W. de Graaf,Albertine Ellen Smit,Frans VanderWerf,Cathy E. Bakker,Rob Willemsen,T. Ikeda,Sho Kakizawa,K. Onodera,David L. Nelson,Edwin Mientjes,M. Joosten,E. De Schutter,Ben A. Oostra,M. Ito,C. I. De Zeeuw +20 more
TL;DR: It is demonstrated that both global and Purkinje cell-specific knockouts of Fmr1 show deficits in classical delay eye-blink conditioning in that the percentage of conditioned responses as well as their peak amplitude and peak velocity are reduced.
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Ultrastructural study of the GABAergic, cerebellar, and mesodiencephalic innervation of the cat medial accessory olive: anterograde tracing combined with immunocytochemistry.
TL;DR: The rostral medial accessory olive of the cat was studied by using an ultrastructural technique combining wheat germ agglutinin–coupled horseradish peroxidase (WGA‐HRP) anterograde tracing and postembedding GABA immunocytochemistry.
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Cerebellar LTD and learning-dependent timing of conditioned eyelid responses.
Sebastiaan K. E. Koekkoek,H. C. Hulscher,Bjorn R. Dortland,Robert A. Hensbroek,Ype Elgersma,Tom J. H. Ruigrok,C. I. De Zeeuw +6 more
TL;DR: It is shown that protein kinase C–dependent long-term depression in Purkinje cells is necessary for learning-dependent timing of Pavlovian-conditioned eyeblink responses.
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Cerebellar modules operate at different frequencies
Haibo Zhou,Zhanmin Lin,Kai Voges,Chiheng Ju,Zhenyu Gao,Laurens W. J. Bosman,Tom J. H. Ruigrok,Freek E. Hoebeek,Chris I. De Zeeuw,Chris I. De Zeeuw,Martijn Schonewille +10 more
TL;DR: It is shown in awake mice at rest that spiking activity of Purkinje cells, the sole output cells of the cerebellar cortex, differs between Cerebellar modules and correlates with their expression of the glycolyticase C or zebrin.