J
Jean-Noël Freund
Researcher at University of Strasbourg
Publications - 147
Citations - 8229
Jean-Noël Freund is an academic researcher from University of Strasbourg. The author has contributed to research in topics: CDX2 & Homeobox. The author has an hindex of 43, co-authored 140 publications receiving 7653 citations. Previous affiliations of Jean-Noël Freund include Max Planck Society & Centre national de la recherche scientifique.
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Journal ArticleDOI
Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway
TL;DR: The results strongly suggest that Axin2 is a direct target of the Wnt pathway, mediated through Tcf/LEF factors, and participates in a negative feedback loop which could serve to limit the duration or intensity of a Wnt-initiated signal.
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SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes
Philippe Blache,Marc van de Wetering,Isabelle Duluc,Claire Domon,Philippe Berta,Jean-Noël Freund,Hans Clevers,Philippe Jay +7 more
TL;DR: In this article, the SOX9 protein was found to be expressed in the intestinal epithelium in a pattern characteristic of Wnt targets, and in vitro and in vivo evidence was provided that a bipartite β-catenin/TCF4 transcription factor, the effector of the Wnt signaling pathway, is required for SOX-9 expression in epithelial cells.
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Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation.
Olivier Lorentz,Isabelle Duluc,Adèle De Arcangelis,Patricia Simon-Assmann,Michèle Kedinger,Jean-Noël Freund +5 more
TL;DR: It is concluded that C dx2 plays a key role in the extracellular matrix–mediated intestinal cell differentiation and provokes pleiotropic effects triggering cells towards the phenotype of differentiated villus enterocytes, and that Cdx2 expression is modulated by basement membrane components.
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Cdx and Hox Genes Differentially Regulate Posterior Axial Growth in Mammalian Embryos
Teddy Young,Jennifer E. Rowland,Cesca van de Ven,Monika Bialecka,Ana Nóvoa,Marta Carapuço,Johan van Nes,Wim de Graaff,Isabelle Duluc,Jean-Noël Freund,Felix Beck,Moisés Mallo,Moisés Mallo,Jacqueline Deschamps +13 more
TL;DR: Hox genes seem to differentially orchestrate posterior expansion of embryonic tissues during axial morphogenesis as an integral part of their function in specifying head-to-tail identity.
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Wnt/beta-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine
Heiko Lickert,C. Domon,G. Huls,Christian Wehrle,Isabelle Duluc,Hans Clevers,Barbara Meyer,Jean-Noël Freund,Rolf Kemler +8 more
TL;DR: In this article, the homeobox gene Cdx1 was found to be a direct target of the Wnt/(beta)-catenin signaling pathway in the human intestinal epithelium.