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Chandrasekhar Kanduri
Researcher at University of Gothenburg
Publications - 90
Citations - 8262
Chandrasekhar Kanduri is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Chromatin & DNA methylation. The author has an hindex of 35, co-authored 84 publications receiving 7099 citations. Previous affiliations of Chandrasekhar Kanduri include Banaras Hindu University & Science for Life Laboratory.
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Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation
Radha Raman Pandey,Tanmoy Mondal,Faizaan Mohammad,Stefan Enroth,Lisa Redrup,Jan Komorowski,Takashi Nagano,Debora Mancini-Dinardo,Chandrasekhar Kanduri +8 more
TL;DR: A mechanism whereby Kcnq1ot1 establishes lineage-specific transcriptional silencing patterns through recruitment of chromatin remodeling complexes and maintenance of these patterns through subsequent cell divisions occurs via targeting the associated regions to the perinucleolar compartment is described.
Journal ArticleDOI
Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra-and interchromosomal interactions
Zhihu Zhao,Gholamreza Tavoosidana,Mikael Sjölinder,Anita Göndör,Piero Mariano,Sha Wang,Chandrasekhar Kanduri,Magda Lezcano,Kuljeet Singh Sandhu,Umashankar Singh,Vinod Pant,Vijay K. Tiwari,Sreenivasulu Kurukuti,Rolf Ohlsson +13 more
TL;DR: It is found that the direct interaction between differentially methylated regions was linked to epigenetic regulation of transcription in trans and the patterns of interactions specific to the maternal H19 imprinting control region underwent reprogramming during in vitro maturation of embryonic stem cells.
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MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures
Tanmoy Mondal,Santhilal Subhash,Roshan Vaid,Stefan Enroth,Sireesha Uday,Björn Reinius,Sanhita Mitra,Arif Mohammed,Alva Rani James,Emily Hoberg,Aristidis Moustakas,Ulf Gyllensten,Steven J.M. Jones,Claes M. Gustafsson,Andrew H. Sims,Fredrik Westerlund,Eduardo Gorab,Chandrasekhar Kanduri +17 more
TL;DR: It is shown that MEG3 and EZH2 share common target genes, including the TGF-β pathway genes, and RNA–DNA triplex formation could be a general characteristic of target gene recognition by the chromatin-interacting lncRNAs.
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Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
Chandrasekhar Kanduri,Vinod Pant,Dmitri Loukinov,Elena M. Pugacheva,Chen Feng Qi,Alan P. Wolffe,Rolf Ohlsson,Victor V. Lobanenkov +7 more
TL;DR: Observations suggest that molecular mechanisms of genomic imprinting may use an unusual ability of CTCF to interact with a diverse spectrum of variant target sites, some of which include CpGs that are responsible for methylation-sensitive C TCF binding in vitro and in vivo.
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BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma
Dmitri Loukinov,Elena M. Pugacheva,Sergei Vatolin,Svetlana Pack,Hanlim Moon,Igor Chernukhin,Poonam Mannan,Erik G. Larsson,Chandrasekhar Kanduri,Alexander A. Vostrov,Hengmi Cui,Emily L. Niemitz,John E.J. Rasko,Malathi K. Kistler,Joseph J. Breen,Zhengping Zhuang,Wolfgang W. Quitschke,Rainer Renkawitz,Elena Klenova,Andrew P. Feinberg,Rolf Ohlsson,Herbert C. Morse,Victor V. Lobanenkov +22 more
TL;DR: It is shown here that erasure of methylation marks during male germ-line development is associated with dramatic up- regulation of BORIS and down-regulation of CTCF expression, and BORis is a candidate protein for the elusive epigenetic reprogramming factor acting in the male germ line.