T
Tomomi Kuwahara
Researcher at Kagawa University
Publications - 120
Citations - 7707
Tomomi Kuwahara is an academic researcher from Kagawa University. The author has contributed to research in topics: Bacteroides fragilis & Bacteroides. The author has an hindex of 28, co-authored 116 publications receiving 6686 citations. Previous affiliations of Tomomi Kuwahara include François Rabelais University & University of Tokushima.
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Journal ArticleDOI
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Koji Atarashi,Takeshi Tanoue,Tatsuichiro Shima,Akemi Imaoka,Tomomi Kuwahara,Yoshika Momose,Genhong Cheng,Sho Yamasaki,Takashi Saito,Yusuke Ohba,Tadatsugu Taniguchi,Kiyoshi Takeda,Shohei Hori,Ivaylo I. Ivanov,Yoshinori Umesaki,Kikuji Itoh,Kenya Honda,Kenya Honda +17 more
TL;DR: Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic immunoglobulin E responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy.
Comparative Metagenomics Revealed Commonly Enriched Gene Sets in
S. Ishikawa,Yoshitoshi Ogura,Mika Yoshimura,Hajime Okumura,E. Cho,Yoshikazu Kawai,Ken Kurokawa,Toshiaki Itoh,Tomomi Kuwahara,Kenshiro Oshima,Hidehiro Toh,Atsushi Toyoda,Hideto Takami,Hidetoshi Morita,Vineet K. Sharma,Tulika P. Srivastava,Todd D. Taylor,Hideki Noguchi,H. Mori,D. S. Ehrlich +19 more
TL;DR: A conjugative transposon family explosively amplified in human gut microbiomes is discovered, which strongly suggests that the intestine is a ‘hot spot’ for horizontal gene transfer between microbes.
Journal ArticleDOI
Comparative Metagenomics Revealed Commonly Enriched Gene Sets in Human Gut Microbiomes
Ken Kurokawa,Takehiko Itoh,Tomomi Kuwahara,Kenshiro Oshima,Hidehiro Toh,Atsushi Toyoda,Hideto Takami,Hidetoshi Morita,Vineet K. Sharma,Tulika P. Srivastava,Todd D. Taylor,Hideki Noguchi,Hiroshi Mori,Yoshitoshi Ogura,Dusko S. Ehrlich,Kikuji Itoh,Toshihisa Takagi,Yoshiyuki Sakaki,Tetsuya Hayashi,Masahira Hattori,Masahira Hattori +20 more
TL;DR: This article performed a large-scale comparative metagenomic analysis of fecal samples from 13 healthy individuals of various ages, including unweaned infants, to identify the genomic features common to all human gut microbiomes as well as those variable among them.
Journal ArticleDOI
Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation
Tomomi Kuwahara,Atsushi Yamashita,Hideki Hirakawa,Haruyuki Nakayama,Hidehiro Toh,Natsumi Okada,Satoru Kuhara,Masahira Hattori,Tetsuya Hayashi,Yoshinari Ohnishi +9 more
TL;DR: At the mucosal surface, where microbes encounter continuous attack by host defenses, BF evasion of the immune system is favored, and its colonization and infectious potential are increased.
Journal ArticleDOI
IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria.
Akira Nakajima,Alexis Vogelzang,Mikako Maruya,Michio Miyajima,Megumi Murata,Aoi Son,Tomomi Kuwahara,Tatsuaki Tsuruyama,Satoshi Yamada,Minoru Matsuura,Hiroshi Nakase,Hiroshi Nakase,Daniel A. Peterson,Sidonia Fagarasan,Keiichiro Suzuki +14 more
TL;DR: A heavily glycosylated monoclonal IgA recognizing ovalbumin coats Bacteroides thetaiotaomicron, a prominent gut symbiont of the phylum Bacteroidetes, revealing a novel mechanism by which IgA promotes symbiosis and colonic homeostasis.