Akemi Imaoka

TL;DR: The authors showed that colonisation of mice with a segmented filamentous bacterium (SFB) is sufficient to induce the appearance of CD4+ T helper cells that produce IL-17 and IL-22 (Th17 cells) in the lamina propria.

TL;DR: Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic immunoglobulin E responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy.

TL;DR: It is shown that adhesion of microbes to intestinal epithelial cells (ECs) is a critical cue for Th17 induction, and a mixture of 20 bacterial strains, which were selected and isolated from fecal samples of a patient with ulcerative colitis on the basis of their ability to cause a robust induction of Th17 cells in the mouse colon, exhibited EC-adhesive characteristics.

TL;DR: It is shown that ILC3-mediated epithelial fucosylation protects the host from invasion of S. typhimurium into the intestine, and the critical role of the cytokines IL-22– and/or LT-producing I LC3 in the induction and regulation of intestinal epithelium fucOSylation is demonstrated.

TL;DR: In this paper, the authors conducted a randomized clinical trial of the use of a bifidobacteria-fermented milk (BFM) supplement as a dietary adjunct in the treatment of ulcerative colitis.