H
Hidehiro Toh
Researcher at Kyushu University
Publications - 79
Citations - 8476
Hidehiro Toh is an academic researcher from Kyushu University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 32, co-authored 76 publications receiving 7374 citations. Previous affiliations of Hidehiro Toh include Kitasato University & Yamaguchi University.
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Journal ArticleDOI
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Shinji Fukuda,Hidehiro Toh,Koji Hase,Kenshiro Oshima,Yumiko Nakanishi,Kazutoshi Yoshimura,Toru Tobe,Julie M. Clarke,David L. Topping,Tohru Suzuki,Todd D. Taylor,Kikuji Itoh,Jun Kikuchi,Jun Kikuchi,Hidetoshi Morita,Masahira Hattori,Hiroshi Ohno,Hiroshi Ohno +17 more
TL;DR: It is proposed that acetate produced by protective bifidobacteria improves intestinal defence mediated by epithelial cells and thereby protects the host against lethal infection.
Comparative Metagenomics Revealed Commonly Enriched Gene Sets in
S. Ishikawa,Yoshitoshi Ogura,Mika Yoshimura,Hajime Okumura,E. Cho,Yoshikazu Kawai,Ken Kurokawa,Toshiaki Itoh,Tomomi Kuwahara,Kenshiro Oshima,Hidehiro Toh,Atsushi Toyoda,Hideto Takami,Hidetoshi Morita,Vineet K. Sharma,Tulika P. Srivastava,Todd D. Taylor,Hideki Noguchi,H. Mori,D. S. Ehrlich +19 more
TL;DR: A conjugative transposon family explosively amplified in human gut microbiomes is discovered, which strongly suggests that the intestine is a ‘hot spot’ for horizontal gene transfer between microbes.
Journal ArticleDOI
Comparative Metagenomics Revealed Commonly Enriched Gene Sets in Human Gut Microbiomes
Ken Kurokawa,Takehiko Itoh,Tomomi Kuwahara,Kenshiro Oshima,Hidehiro Toh,Atsushi Toyoda,Hideto Takami,Hidetoshi Morita,Vineet K. Sharma,Tulika P. Srivastava,Todd D. Taylor,Hideki Noguchi,Hiroshi Mori,Yoshitoshi Ogura,Dusko S. Ehrlich,Kikuji Itoh,Toshihisa Takagi,Yoshiyuki Sakaki,Tetsuya Hayashi,Masahira Hattori,Masahira Hattori +20 more
TL;DR: This article performed a large-scale comparative metagenomic analysis of fecal samples from 13 healthy individuals of various ages, including unweaned infants, to identify the genomic features common to all human gut microbiomes as well as those variable among them.
Journal ArticleDOI
The 160-Kilobase Genome of the Bacterial Endosymbiont Carsonella
Atsushi Nakabachi,Atsushi Yamashita,Hidehiro Toh,Hajime Ishikawa,Helen E. Dunbar,Nancy A. Moran,Masahira Hattori +6 more
TL;DR: The complete genome sequence of the psyllid symbiont Carsonella ruddii is reported, which is by far the smallest and most AT-rich bacterial genome yet characterized and has a high coding density with many overlapping genes and reduced gene length.
Journal ArticleDOI
Derivation of Human Trophoblast Stem Cells
Hiroaki Okae,Hidehiro Toh,Tetsuya Sato,Hitoshi Hiura,Sota Takahashi,Kenjiro Shirane,Yuka Kabayama,Mikita Suyama,Hiroyuki Sasaki,Takahiro Arima +9 more
TL;DR: It is shown that activation of Wingless/Integrated and EGF and inhibition of TGF-β, histone deacetylase, and Rho-associated protein kinase enable long-term culture of human villous cytotrophoblast (CT) cells, which will provide a powerful tool to study human trophoblast development and function.