Tomomi Shimogori

TL;DR: In Scale-treated mouse brain, neurons labeled with genetically encoded fluorescent proteins were visualized at an unprecedented depth in millimeter-scale networks and at subcellular resolution, suggesting that the Scale method will be useful for light microscopy–based connectomics of cellular networks in brain and other tissues.

TL;DR: A detailed molecular atlas of the developing hypothalamus was constructed and markers that stably labeled each major hypothalamic nucleus over the entire course of neurogenesis were used to analyze the phenotype of mice in which Sonic Hedgehog was selectively deleted from hypothalamic neuroepithelium and found that Shh is essential for anterior hypothalamic patterning.

TL;DR: The cloning and characterization of UnaG, a fluorescent protein from Japanese eel, is reported, which will be the prototype for a versatile class of ligand-activated fluorescent proteins, with applications in research, medicine, and bioengineering.

TL;DR: The results suggest that TBK1-mediated S403 phosphorylation regulates the efficient autophagosomal engulfment of ubiquitinated mitochondria as an immediate response to the mitochondrial depolarization.

TL;DR: A novel role for bHLH genes in the process of deciding which cells will have a non-neural versus a neural fate is identified, and it is found that the prospective choroid plexus region initially gives rise to Cajal-Retzius cells, specialized neurons that guide neuronal migration.