T
Tomoyuki Yamaguchi
Researcher at Osaka University
Publications - 42
Citations - 15617
Tomoyuki Yamaguchi is an academic researcher from Osaka University. The author has contributed to research in topics: FOXP3 & IL-2 receptor. The author has an hindex of 25, co-authored 35 publications receiving 14128 citations. Previous affiliations of Tomoyuki Yamaguchi include Aix-Marseille University & University of Tokyo.
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Journal ArticleDOI
Regulatory T Cells and Immune Tolerance
TL;DR: The cellular and molecular basis of Treg development and function is revealed and dysregulation of T Regs in immunological disease is implicates.
Journal ArticleDOI
CTLA-4 Control over Foxp3+ Regulatory T Cell Function
Kajsa Wing,Yasushi Onishi,Yasushi Onishi,Paz Prieto-Martin,Tomoyuki Yamaguchi,Makoto Miyara,Zoltan Fehervari,Takashi Nomura,Shimon Sakaguchi,Shimon Sakaguchi +9 more
TL;DR: It is shown that a specific deficiency of cytotoxic T lymphocyte antigen 4 (CTLA-4) in Tregs results in spontaneous development of systemic lymphoproliferation, fatal T cell–mediated autoimmune disease, and hyperproduction of immunoglobulin E in mice.
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Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
Makoto Miyara,Yumiko Yoshioka,Akihiko Kitoh,Tomoko Shima,Kajsa Wing,Akira Niwa,Christophe Parizot,Cécile Taflin,Toshio Heike,Dominique Valeyre,Alexis Mathian,Tatsutoshi Nakahata,Tomoyuki Yamaguchi,Takashi Nomura,Masahiro Ono,Zahir Amoura,Guy Gorochov,Guy Gorochov,Shimon Sakaguchi,Shimon Sakaguchi +19 more
TL;DR: The dissection of FoxP3(+) cells into subsets enables one to analyze Treg cell differentiation dynamics and interactions in normal and disease states, and to control immune responses through manipulating particular FoxP 3(+) subpopulations.
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Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
Keiji Hirota,Hiroyuki Yoshitomi,Motomu Hashimoto,Shinji Maeda,Shin Teradaira,Naoshi Sugimoto,Tomoyuki Yamaguchi,Takashi Nomura,Hiromu Ito,Takashi Nakamura,Noriko Sakaguchi,Shimon Sakaguchi +11 more
TL;DR: The results indicate that CCR6 expression contributes to Th17 cell function in autoimmune disease, especially in autoimmune arthritis such as RA.
Journal ArticleDOI
Regulatory T cells: how do they suppress immune responses?
Shimon Sakaguchi,Shimon Sakaguchi,Kajsa Wing,Kajsa Wing,Yasushi Onishi,Yasushi Onishi,Paz Prieto-Martin,Tomoyuki Yamaguchi +7 more
TL;DR: This work proposes that there may be a key suppressive mechanism that is shared by every forkhead box p3 (Foxp3)(+) Treg in vivo and in vitro in mice and humans and will help to design effective ways for controlling immune responses by targeting Treg suppressive functions.