T
Tor Ole Klemsdal
Researcher at Oslo University Hospital
Publications - 56
Citations - 2784
Tor Ole Klemsdal is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Medicine & Randomized controlled trial. The author has an hindex of 18, co-authored 51 publications receiving 2211 citations. Previous affiliations of Tor Ole Klemsdal include St Bartholomew's Hospital & University of Oslo.
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Journal ArticleDOI
Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial
Paul M. Ridker,Jean G. MacFadyen,Tom Thuren,Brendan M. Everett,Peter Libby,R J Glynn,Paul Ridker,Alberto J. Lorenzatti,Henry Krum,John Varigos,Peter Siostrzonek,Peter Sinnaeve,Francisco Antonio Helfenstein Fonseca,Jose C. Nicolau,Nina Gotcheva,Jacques Genest,Huo Yong,Miguel Urina-Triana,Davor Miličić,Renata Cifkova,Riina Vettus,Wolfgang Koenig,Stephan D Anker,Athanasios J. Manolis,Fernando Wyss,Tamás Forster,Axel Sigurdsson,Prem Pais,Alessandro Fucili,Hisao Ogawa,Hiroaki Shimokawa,Irina Veze,Birute Petrauskiene,Leon Salvador,John J.P. Kastelein,Jan H. Cornel,Tor Ole Klemsdal,Félix Medina,Andrzej Budaj,Luminita Vida-Simiti,Zhanna Kobalava,Petar Otasevic,Daniel Pella,Mitja Lainscak,Ki-Bae Seung,Patrick J. Commerford,Mikael Dellborg,Marc Y. Donath,Juey-Jen Hwang,Hakan Kultursay,Marcus Flather,Christie M. Ballantyne,Seth Bilazarian,William Chang,Cara East,Brendan Everett,Les Forgosh,Robert J. Glynn,Barry Harris,Monica Ligueros,Erin A. Bohula,Bindu Charmarthi,Susan Cheng,Sherry Chou,Jacqueline Danik,Graham McMahon,Bradley Maron,MingMing Ning,Benjamin Olenchock,Reena Pande,Todd Perlstein,Aruna D. Pradhan,Natalia Rost,Aneesh Singhal,Viviany Taqueti,Nancy Wei,Howard A. Burris,Angela Cioffi,Anne Marie Dalseg,Nilanjan Ghosh,Julie R. Gralow,Tina Mayer,Hope S. Rugo,Vance G. Fowler,Ajit P. Limaye,Sara Cosgrove,Donald Levine,Renato D. Lopes,John D. Scott,Robert Hilkert,Georgia Tamesby,Carolyn Mickel,Brian Manning,Julian Woelcke,Monique Tan,Sheryl Manfreda,Tom Ponce,Jane Kam,Ravinder Saini,Kehur Banker,Thomas Salko,Panjat Nandy,Ronda Tawfik,Greg O'Neil,Shobha Manne,Pravin Jirvankar,Shankar Lal,Deepak Nema,Jaison Jose,Rory Collins,Kent Bailey,Roger S. Blumenthal,Helen M. Colhoun,Bernard J. Gersh +113 more
TL;DR: The hypothesis-generating data suggest the possibility that anti-inflammatory therapy with canakinumab targeting the interleukin-1β innate immunity pathway could significantly reduce incident lung cancer and lung cancer mortality.
Journal ArticleDOI
Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial
Paul M. Ridker,Jean G. MacFadyen,Brendan M. Everett,Peter Libby,Tom Thuren,Robert J. Glynn,John J.P. Kastelein,Wolfgang Koenig,Jacques Genest,Alberto J. Lorenzatti,John Varigos,Peter Siostrzonek,Peter Sinnaeve,Francisco Antonio Helfenstein Fonseca,Jose C. Nicolau,Nina Gotcheva,Huo Yong,Miguel Urina-Triana,Davor Miličić,Renata Cifkova,Riina Vettus,Stephan D Anker,Athanasios J. Manolis,Fernando Wyss,Tamás Forster,Axel Sigurdsson,Prem Pais,Alessandro Fucili,Hisao Ogawa,Hiroaki Shimokawa,Irina Veze,Birute Petrauskiene,Leon Salvador,Jan H. Cornel,Tor Ole Klemsdal,Félix Medina,Andrzej Budaj,Luminita Vida-Simiti,Zhanna Kobalava,Petar Otasevic,Daniel Pella,Mitja Lainscak,Ki-Bae Seung,Patrick J. Commerford,Mikael Dellborg,Marc Y. Donath,Juey-Jen Hwang,Hakan Kultursay,Marcus Flather,Christie M. Ballantyne,Seth Bilazarian,William Chang,Cara East,Les Forgosh,Barry Harris,Monica Ligueros +55 more
TL;DR: The magnitude of hsCRP reduction following a single dose of canakinumab might provide a simple clinical method to identify individuals most likely to accrue the largest benefit from continued treatment, and suggest that lower is better for inflammation reduction with canakinUMab.
Journal ArticleDOI
3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial
Carel W. le Roux,Carel W. le Roux,Arne Astrup,Ken Fujioka,Frank Greenway,David C.W. Lau,Luc Van Gaal,Rafael Violante Ortiz,John P H Wilding,Trine Vang Skjøth,Linda Shapiro Manning,Xavier Pi-Sunyer,Andreas Hamann,Alain Barakat,Matthias Blüher,Thomas Linn,Andrea Mölle,Alexander Segner,Petra Stübler,Regina Tosch-Sisting,Furio Pacini,Ferruccio Santini,Giulio Marchesini,Carlo Maria Rotella,Cecilia Invitti,Roberto Vettor,Silvio Buscemi,Pedro Mezquita Raya,Felipe Casanueva Freijoo,Ramón Gomis de Barbará,Raffaele Carraro,Enrique Romero Bobillo,Carmen de la Cuesta,Csaba Farsang,Albert Császár,Barbara Zahorska-Markiewicz,Danuta Pupek-Musialik,Edward Franek,Lucyna Ostrowska,Magdalena Olszanecka-Glinianowicz,N. Lalic,Dragan Micic,Bernhard Ludvik,Bernhard Paulweber,Rudolf Prager,André Scheen,Astrup Av,Kjeld Hermansen,Sten Madsbad,Aila Rissanen,Sakari Nieminen,Markku J. Savolainen,Michel Krempf,Monique Romon,Martine Laville,Michel Marre,Reginald Mira,Francis M. Finucane,Aletha Veenendaal,Frank van Berkum,Solrun Johannsson-Vidarsdóttir,Vivienne Van de Walle,Eelco Meesters,Jøran Hjelmesæth,Tor Ole Klemsdal,Bård Kulseng,Birgit Bach-Kliegel,Kurt Laederach,Lukas Villiger,Alain Golay,Stefan Bilz,Thozhukat Sathyapalan,Stephen C. Bain,Sudesh Kumar,Carel Wynard Le Roux,Michael E. J. Lean,Barbara McGowan,Tariq Rehman,John P.H. Wilding,Gary A. Wittert,Ian D. Caterson,Joeseph Proietto,John Prins,Bruno Geloneze Neto,Jorge Luiz Gross,Antonio Roberto Chacra,Alfredo Halpern,Henrique de Almeida Suplicy,Francis Chun Chung Chow,Hemant P Thacker,Manoj Chadha,Hemaraj Chandalia,Ambika Gopalakrishnan Unnikrishnan,Sanjay Kalra,Neeta Deshpande,Minakshi Shunmugavelu,Vaishali Deshmukh,Maximo Maislos,Gabriella Segal Lieberman,Ilan Shimon,Naftali Stern,Dan Nabriski,Eddy Karnieli,Naim Shehadeh,Guillermo Gonzalez-Galvez,Maria del Rosario Arechavaleta-Granell,Rafael Violante Ortiz,Guadalupe Morales Franco,Irina Gurieva,Lyudmila Aleksandrovna Suplotova,Ekaterina A. Troshina,Ludmila Aleksandrovna Ruyatkina,Emma Anatolievna Voychik,Sergey Martsevich,Maria A Startseva,Mary Elizabeth Seeber,Aysha Badat,Graham Ellis,Yuksel Altuntas,Serdar Güler,Ender Ulgen,Tuncay Delibasi,Tony Chetty,Randy Hart,Jeannette Janzen,Isabelle Labonte,David C.W. Lau,Joanne Liutkus,Dennis O'Keefe,Raj Padwal,Thomas Ransom,Richard Tytus,Stanley John Weisnagel,Jay Adler,Keith Aqua,S. Aronoff,Gary W. Bedel,Thomas Craig Blevins,Joe Blumenau,Andrew Peter Brockmyre,Robert S Call,Rafael Canadas,Louis B Chaykin,Kenneth Cohen,Jeffrey Keith Conrow,Matthew G Davis,H Jackson Downey,Steven Richard Drosman,Steven Duckor,H. Frank Farmer,James Farrell,Stephen Fehnel,Matthew Patrick Finneran,Ray Forbes,Alan Forker,Mark Fredrick,Steven Andrew Geller,Santosh Gill,Linda Glaser,Susan Neims Greco,Frank L. Greenway,Wayne Harper,Lee Herman,John Hoekstra,Richard Ingebretsen,Rodney Ison,Rajeev K Jain,Roy Kaplan,Steven Richard Kaster,Gregory A Haase,Boris Kerzner,Judith Lee Kirstein,William Koltun,Diane R Krieger,Cora E. Lewis,Robert Madder,Richard N Marple,Edward J McDermott,Curtis John Mello,Alan B. Miller,Julie Mullen,John Nardandrea,Patrick M. O'Neil,F. Xavier Pi-Sunyer,Ronald M Pucillo,Chanhaeng Rhee,Scott Redrick,Aaron Pardini,Jeffrey Rothman,Domenica Rubino,Gladstone Sellers,Timothy Smith,William David Byars,Joseph Soufer,Allen Michael Sussman,Kyle Patrick,Erich Lloyd Schramm,Martin Van Cleeff,Saul Reuel Berg,Holly R. Wyatt,James Alan Simon +200 more
TL;DR: Liraglutide 3·0 mg might provide health benefits in terms of reduced risk of diabetes in individuals with obesity and prediabetes in this trial, with the limitation that withdrawn individuals were not followed up after discontinuation.
Journal ArticleDOI
Predictors of Elevated B-Type Natriuretic Peptide Concentrations in Dyspneic Patients Without Heart Failure: An Analysis From the Breathing Not Properly Multinational Study
Cathrine Wold Knudsen,Paul Clopton,Arne Westheim,Tor Ole Klemsdal,Alan H.B. Wu,Philippe Duc,James McCord,Richard M. Nowak,Judd E. Hollander,Alan B. Storrow,William T. Abraham,Peter A. McCullough,Alan S. Maisel,Torbjørn Omland +13 more
TL;DR: Independent predictors of elevated BNP levels were a medical history of atrial fibrillation, radiographic cardiomegaly, decreased blood hemoglobin concentration, decreased body mass index, and increased age.
Journal ArticleDOI
Effect of diet or very long chain ω-3 fatty acids on progression of atherosclerosis, evaluated by carotid plaques, intima-media thickness and by pulse wave propagation in elderly men with hypercholesterolaemia:
Elsa M. Hjerkinn,Michael Abdelnoor,Liv Breivik,Lise Bergengen,Ingrid Ellingsen,Ingebjørg Seljeflot,Ottar Aase,Tor Ole Klemsdal,Ingvar Hjermann,Harald Arnesen +9 more
TL;DR: In this paper, a randomized study targeted a comparison of the effect of 3-year diet counselling or ω-3 polyunsaturated fatty acid (PUFA) supplementation (2.4g/day) on the progression of atherosclero...