T
Toshihiko Shiraiwa
Researcher at Osaka University
Publications - 68
Citations - 1439
Toshihiko Shiraiwa is an academic researcher from Osaka University. The author has contributed to research in topics: Diabetes mellitus & Type 2 diabetes. The author has an hindex of 16, co-authored 62 publications receiving 1227 citations.
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Journal ArticleDOI
Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation
Takeshi Miyatsuka,Hideaki Kaneto,Toshihiko Shiraiwa,Taka-aki Matsuoka,Kaoru Yamamoto,Ken Kato,Y. Nakamura,Shizuo Akira,Kiyoshi Takeda,Yoshitaka Kajimoto,Yoshimitsu Yamasaki,Eric P. Sandgren,Yoshiya Kawaguchi,Christopher V.E. Wright,Yoshio Fujitani +14 more
TL;DR: A mechanism of pancreatic metaplasia is provided by which persistent PDX-1 expression cell-autonomously induces acinar-to-ductal transition through Stat3 activation, and genetic ablation of Stat3 in the transgenic pancreas profoundly suppressed the metaplastic phenotype.
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PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell function.
Hideaki Kaneto,Takeshi Miyatsuka,Dan Kawamori,Kaoru Yamamoto,Ken Kato,Toshihiko Shiraiwa,Naoto Katakami,Yoshimitsu Yamasaki,Munehide Matsuhisa,Taka-aki Matsuoka +9 more
TL;DR: Under diabetic conditions, expression and/or activities of PDX-1 and MafA in beta-cells are reduced, which leads to suppression of insulin biosynthesis and secretion, likely that alteration of such transcription factors explains, at least in part, the molecular mechanism for beta-cell glucose toxicity found in diabetes.
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Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A).
Tomoya Mita,Naoto Katakami,Hidenori Yoshii,Tomio Onuma,Hideaki Kaneto,Takeshi Osonoi,Toshihiko Shiraiwa,Keisuke Kosugi,Yutaka Umayahara,Tsunehiko Yamamoto,Hiroki Yokoyama,Nobuichi Kuribayashi,Hideaki Jinnouchi,Masahiko Gosho,Iichiro Shimomura,Hirotaka Watada +15 more
TL;DR: Alogliptin treatment attenuated the progression of carotid IMT in patients with T2DM free of apparent cardiovascular disease compared with the conventional treatment, and had a more potent glucose-lowering effect.
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Sitagliptin attenuates the progression of carotid intima-media thickening in insulin-treated patients with type 2 diabetes: The sitagliptin preventive study of intima-media thickness evaluation (SPIKE): A randomized controlled trial
Tomoya Mita,Naoto Katakami,Toshihiko Shiraiwa,Hidenori Yoshii,Tomio Onuma,Nobuichi Kuribayashi,Takeshi Osonoi,Hideaki Kaneto,Keisuke Kosugi,Yutaka Umayahara,Tsunehiko Yamamoto,Kazunari Matsumoto,Hiroki Yokoyama,Mamiko Tsugawa,Masahiko Gosho,Iichiro Shimomura,Hirotaka Watada +16 more
TL;DR: Sitagliptin attenuated the progression of carotid IMT in insulin-treated patients with T2DM free of apparent cardiovascular disease compared with conventional treatment, without increasing hypoglycemic episodes or body weight.
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Post-prandial hyperglycemia is an important predictor of the incidence of diabetic microangiopathy in Japanese type 2 diabetic patients
Toshihiko Shiraiwa,Hideaki Kaneto,Takeshi Miyatsuka,Ken Kato,Kaoru Yamamoto,Ayaha Kawashima,Tsutomu Kanda,Masaaki Suzuki,Eiichi Imano,Munehide Matsuhisa,Masatsugu Hori,Yoshimitsu Yamasaki +11 more
TL;DR: Post-prandial hyperglycemia, rather than fasting glycemia or hemoglobin A1c levels, is an important predictor of the incidence of diabetic microangiopathy in Japanese type 2 diabetic patients.