K
Ken Ishiyama
Researcher at Kanazawa University
Publications - 118
Citations - 4378
Ken Ishiyama is an academic researcher from Kanazawa University. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 19, co-authored 98 publications receiving 3654 citations.
Papers
More filters
Journal ArticleDOI
Frequent pathway mutations of splicing machinery in myelodysplasia
Kenichi Yoshida,Masashi Sanada,Yuichi Shiraishi,Daniel Nowak,Yasunobu Nagata,Ryo Yamamoto,Yusuke Sato,Aiko Sato-Otsubo,Ayana Kon,Masao Nagasaki,George Chalkidis,Yutaka Suzuki,Masashi Shiosaka,Ryoichiro Kawahata,Tomoyuki Yamaguchi,Makoto Otsu,Naoshi Obara,Mamiko Sakata-Yanagimoto,Ken Ishiyama,Hiraku Mori,Florian Nolte,Wolf-Karsten Hofmann,Shuichi Miyawaki,Sumio Sugano,Claudia Haferlach,H. Phillip Koeffler,H. Phillip Koeffler,Lee Yung Shih,Torsten Haferlach,Shigeru Chiba,Hiromitsu Nakauchi,Satoru Miyano,Seishi Ogawa +32 more
TL;DR: The results provide the first evidence indicating that genetic alterations of the major splicing components could be involved in human pathogenesis, also implicating a novel therapeutic possibility for myelodysplasia.
Journal ArticleDOI
Integrated molecular analysis of adult T cell leukemia/lymphoma
Keisuke Kataoka,Yasunobu Nagata,Akira Kitanaka,Yuichi Shiraishi,Teppei Shimamura,Jun-ichirou Yasunaga,Yasushi Totoki,Kenichi Chiba,Aiko Sato-Otsubo,Genta Nagae,Ryohei Ishii,Satsuki Muto,Shinichi Kotani,Yosaku Watatani,June Takeda,Masashi Sanada,Hiroko Tanaka,Hiromichi Suzuki,Yusuke Sato,Yusuke Shiozawa,Tetsuichi Yoshizato,Kenichi Yoshida,Hideki Makishima,Masako Iwanaga,Guangyong Ma,Kisato Nosaka,Masakatsu Hishizawa,Hidehiro Itonaga,Yoshitaka Imaizumi,Wataru Munakata,Hideaki Ogasawara,Toshitaka Sato,Ken Sasai,Kenzo Muramoto,Marina Penova,Takahisa Kawaguchi,Hiromi Nakamura,Natsuko Hama,Kotaro Shide,Yoko Kubuki,Tomonori Hidaka,Takuro Kameda,Tsuyoshi Nakamaki,Ken Ishiyama,Shuichi Miyawaki,Sung-Soo Yoon,Kensei Tobinai,Yasushi Miyazaki,Akifumi Takaori-Kondo,Fumihiko Matsuda,Kengo Takeuchi,Osamu Nureki,Hiroyuki Aburatani,Toshiki Watanabe,Tatsuhiro Shibata,Masao Matsuoka,Satoru Miyano,Kazuya Shimoda,Seishi Ogawa +58 more
TL;DR: The identified alterations overlap significantly with the HTLV-1 Tax interactome and are highly enriched for T cell receptor–NF-κB signaling, T cell trafficking and other T cell–related pathways as well as immunosurveillance.
Journal ArticleDOI
Frequent Pathway Mutations of Splicing Machinery in Myelodysplasia
Kenichi Yoshida,Masashi Sanada,Yuichi Shiraishi,Daniel Nowak,Yasunobu Nagata,Ryo Yamamoto,Yusuke Sato,Aiko Sato-Otsubo,Ayana Kon,Masao Nagasaki,George Chalkidis,Yutaka Suzuki,Makoto Otsu,Naoshi Obara,Mamiko Sakata-Yanagimoto,Ken Ishiyama,Hiraku Mori,Florian Nolte,Wolf-Karsten Hofmann,Shuichi Miyawaki,Sumio Sugano,Claudia Haferlach,H. Phillip Koeffler,Lee-Yung Shih,Torsten Haferlach,Shigeru Chiba,Hiromitsu Nakauchi,Satoru Miyano,Seishi Ogawa +28 more
TL;DR: In this article, the authors performed whole-exome sequencing of 29 cases showing myelodysplasia and identified a total of 268 somatic mutations or 9.2 mutations per sample were identified.
Journal ArticleDOI
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms
Ayana Kon,Lee Yung Shih,Masashi Minamino,Masashi Sanada,Masashi Sanada,Yuichi Shiraishi,Yasunobu Nagata,Kenichi Yoshida,Yusuke Okuno,Masashige Bando,Ryuichiro Nakato,Shumpei Ishikawa,Shumpei Ishikawa,Aiko Sato-Otsubo,Genta Nagae,Aiko Nishimoto,Claudia Haferlach,Daniel Nowak,Yusuke Sato,Tamara Alpermann,Masao Nagasaki,Teppei Shimamura,Hiroko Tanaka,Kenichi Chiba,Ryo Yamamoto,Tomoyuki Yamaguchi,Makoto Otsu,Naoshi Obara,Mamiko Sakata-Yanagimoto,Tsuyoshi Nakamaki,Ken Ishiyama,Florian Nolte,Wolf-Karsten Hofmann,Shuichi Miyawaki,Shigeru Chiba,Hiraku Mori,Hiromitsu Nakauchi,H. Phillip Koeffler,H. Phillip Koeffler,Hiroyuki Aburatani,Torsten Haferlach,Katsuhiko Shirahige,Satoru Miyano,Seishi Ogawa,Seishi Ogawa +44 more
TL;DR: A role for compromised cohesin functions in myeloid leukemogenesis is suggested by the growth of leukemic cell lines harboring a mutation in RAD21 or having severely reduced expression of RAD21 and STAG2 being suppressed by forced expression of wild-type RAD21 (Kasumi-1 cells and MOLM-13 cells).
Journal ArticleDOI
Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma.
Keisuke Kataoka,Masako Iwanaga,Jun-ichirou Yasunaga,Yasunobu Nagata,Akira Kitanaka,Takuro Kameda,Makoto Yoshimitsu,Yuichi Shiraishi,Aiko Sato-Otsubo,Masashi Sanada,Kenichi Chiba,Hiroko Tanaka,Yotaro Ochi,Kosuke Aoki,Hiromichi Suzuki,Yusuke Shiozawa,Tetsuichi Yoshizato,Yusuke Sato,Kenichi Yoshida,Kisato Nosaka,Masakatsu Hishizawa,Hidehiro Itonaga,Yoshitaka Imaizumi,Wataru Munakata,Kotaro Shide,Yoko Kubuki,Tomonori Hidaka,Tsuyoshi Nakamaki,Ken Ishiyama,Shuichi Miyawaki,Ryohei Ishii,Osamu Nureki,Kensei Tobinai,Yasushi Miyazaki,Akifumi Takaori-Kondo,Tatsuhiro Shibata,Satoru Miyano,Kenji Ishitsuka,Atae Utsunomiya,Kazuya Shimoda,Masao Matsuoka,Toshiki Watanabe,Seishi Ogawa +42 more
TL;DR: Somatic alterations characterizing aggressive diseases predict worse prognosis in indolent ATL, among which PD-L1 amplifications are a strong genetic predictor in both aggressive and indolENT ATL.