T
Toshio Moriya
Researcher at KEK
Publications - 10
Citations - 87
Toshio Moriya is an academic researcher from KEK. The author has contributed to research in topics: Resolution (electron density) & RNase P. The author has an hindex of 2, co-authored 10 publications receiving 14 citations.
Papers
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Journal ArticleDOI
Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole.
Tatsuki Asai,Naruhiko Adachi,Toshio Moriya,Hideyuki Oki,Takamitsu Maru,Masato Kawasaki,Kano Suzuki,Sisi Chen,Ryohei Ishii,Kazuko Yonemori,Shigeru Igaki,Satoshi Yasuda,Satoshi Ogasawara,Toshiya Senda,Takeshi Murata +14 more
TL;DR: In this paper, the authors obtained the 3.5-A density map of a potassium-bound hERG channel complexed with astemizole, a well-known hERG inhibitor that increases risk of potentially fatal arrhythmia.
Journal ArticleDOI
Structural and Functional Analyses of the Tridomain-Nonribosomal Peptide Synthetase FmoA3 for 4-Methyloxazoline Ring Formation.
Yohei Katsuyama,Kaoru Sone,Ayaka Harada,Seiji Kawai,Naoki Urano,Naruhiko Adachi,Toshio Moriya,Masato Kawasaki,Kazuo Shin-ya,Toshiya Senda,Yasuo Ohnishi +10 more
TL;DR: In this paper, the authors determined the head-to-tail homodimeric structures of FmoA3 by X-ray crystallography ( apo-form, with adenylyl-imidodiphosphate and α -methyl- l -seryl-AMP) and performed site-directed mutagenesis experiments.
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Non-conventional octameric structure of C-phycocyanin.
Takuo Minato,Takuo Minato,Takamasa Teramoto,Naruhiko Adachi,Nguyen Khac Hung,Kaho Yamada,Masato Kawasaki,Masato Akutsu,Toshio Moriya,Toshiya Senda,Seiji Ogo,Yoshimitsu Kakuta,Ki Seok Yoon +12 more
TL;DR: In this article, the structural characterization of non-conventional octameric C-phycocyanin (CPC) was reported for the first time, and an unusual dimeric state, observed via analytical ultracentrifugation, was postulated to be a key intermediate structure in the assemble of the previously unobserved octamer.
Posted ContentDOI
Size matters: optimal mask diameter and box size for single-particle cryogenic electron microscopy
Toshio Moriya,Naruhiko Adachi,Masato Kawasaki,Yusuke Yamada,Akira Shinoda,Kotaro Koiwai,Fumiaki Yumoto,Toshiya Senda +7 more
TL;DR: Considering the defocus distributions of the datasets, merely optimizing the mask diameters and box sizes yielded meaningful resolution improvements for the reconstruction of < 200 kDa proteins using 200 kV cryo-EM.
Journal ArticleDOI
C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes.
Takahiro Mori,Takahiro Mori,Takuto Kumano,Haibing He,Satomi Watanabe,Miki Senda,Toshio Moriya,Naruhiko Adachi,Sanae Hori,Yuzu Terashita,Masato Kawasaki,Yoshiteru Hashimoto,Takayoshi Awakawa,Toshiya Senda,Toshiya Senda,Ikuro Abe,Michihiko Kobayashi +16 more
TL;DR: In this paper, the activation of xenobiotic C-glycosides by heterocomplex C-deglycosylation enzymes from intestinal and soil bacteria was identified and the structural and catalytic mechanisms of these enzymes were investigated.