T
Tsing-Bau Chen
Researcher at United States Military Academy
Publications - 70
Citations - 3873
Tsing-Bau Chen is an academic researcher from United States Military Academy. The author has contributed to research in topics: Angiotensin II & Angiotensin II receptor type 1. The author has an hindex of 24, co-authored 70 publications receiving 3676 citations. Previous affiliations of Tsing-Bau Chen include Merck & Co..
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Journal ArticleDOI
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists
Ben E. Evans,Kenneth E. Rittle,Mark G. Bock,Robert M. DiPardo,Roger M. Freidinger,W. L. Whitter,George F. Lundell,Daniel F. Veber,Paul S. Anderson,Raymond S.L. Chang,Victor J. Lotti,D. J. Cerino,Tsing-Bau Chen,Paul J. Kling,K. A. Kunkel,James P. Springer,J. Hirshfield +16 more
TL;DR: 3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described, and the method of development of these compounds is discussed in terms of its relevance to the general problem of drug discovery.
Journal ArticleDOI
A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models
Gene G. Kinney,Julie A. O'Brien,Wei Lemaire,Maryann Burno,Denise J. Bickel,Michelle K. Clements,Tsing-Bau Chen,David D. Wisnoski,Craig W. Lindsley,Philip R. Tiller,Sheri Smith,Marlene A. Jacobson,Cyrille Sur,Mark E. Duggan,Douglas J. Pettibone,P. Jeffrey Conn,David L. Williams +16 more
TL;DR: It is demonstrated that positive allosteric modulation of mGluR5 produces behavioral effects, suggesting that such modulation serves as a viable approach to increasing mGLUR5 activity in vivo.
Journal ArticleDOI
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
Julie A. O'Brien,Wei Lemaire,Tsing-Bau Chen,Raymond S.L. Chang,Marlene A. Jacobson,Sookhee Ha,Craig W. Lindsley,Hervé Schaffhauser,Cyrille Sur,Douglas J. Pettibone,P. Jeffrey Conn,David L. Williams +11 more
TL;DR: Evidence that allosteric sites on GPCRs can respond to closely related ligands with a range of pharmacological activities from positive to negative modulation as well as to neutral competition of this modulation is provided.
Journal ArticleDOI
Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood-brain barrier.
Sajedeh Eftekhari,Christopher A. Salvatore,Sara Johansson,Tsing-Bau Chen,Zhizhen Zeng,Lars Edvinsson +5 more
TL;DR: CGRP receptor binding sites and expression of the C GRP receptor in rhesus and rat TG are demonstrated and the expression pattern of PACAP and glutamate suggests a possible interaction between the glutamatergic and CGRP system.
Journal ArticleDOI
Methods for Drug Discovery: Development of Potent, Selective, Orally Effective Cholecystokinin Antagonists.
Ben E. Evans,Kenneth E. Rittle,Mark G. Bock,Robert M. DiPardo,Roger M. Freidinger,W. L. Whitter,George F. Lundell,Daniel F. Veber,Paul S. Anderson,Raymond S.L. Chang,Victor J. Lotti,D. J. Cerino,Tsing-Bau Chen,Paul J. Kling,K. A. Kunkel,James P. Springer,J. Hirshfield +16 more
TL;DR: In this article, 3.3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described.