Tyler T. Hickman

TL;DR: A cell-permeable small molecule (JQ1) that binds competitively to acetyl-lysine recognition motifs, or bromodomains is reported, establishing proof-of-concept for targeting protein–protein interactions of epigenetic ‘readers’, and providing a versatile chemical scaffold for the development of chemical probes more broadly throughout the b romodomain family.

TL;DR: Stress granule condensation of translationally arrested mRNAs requires G3BP and requires its RGG region for SGC and for interactions with 40S ribosomal subunits.

TL;DR: It is shown that ANG inhibits protein synthesis and promotes arsenite- and pateamine A-induced assembly of stress granules (SGs) that are abrogated in cells transfected with the ANG inhibitor RNH1.

TL;DR: Together, these data suggest that BRD–NUT fusion proteins contribute to carcinogenesis by associating with chromatin and interfering with epithelial differentiation.

TL;DR: The results suggest that O-GlcNAc modification of the translational machinery is required for aggregation of untranslated messenger ribonucleoproteins into SGs and the lack of enzymes of the hexosamine biosynthetic pathway in budding yeast may contribute to differences between mammalian SGs