Elizabeth M. Morse

TL;DR: A cell-permeable small molecule (JQ1) that binds competitively to acetyl-lysine recognition motifs, or bromodomains is reported, establishing proof-of-concept for targeting protein–protein interactions of epigenetic ‘readers’, and providing a versatile chemical scaffold for the development of chemical probes more broadly throughout the b romodomain family.

TL;DR: A unique bead-based strategy is developed for the identification of inducers of fetal hemoglobin transcripts in primary human erythroid cells and the potential of isoform-selective inhibitors of HDAC1 and HDAC2 for the treatment of sickle cell disease is suggested.

TL;DR: It is demonstrated that sIL7Rα potentiates IL-7 bioactivity and provides a basis to explain the increased risk of autoimmunity observed in individuals with genotype-induced elevations of sIL6Rα.

TL;DR: Key integrin-interacting proteins are reviewed and their roles in regulating integrin activity, localization, and signaling are reviewed.

TL;DR: This work demonstrates the existence of a mechanically based initiation molecule, syndecan-4, and finds ERK phosphorylation similar to that shown for mechanotransductive response for integrin-based cell attachments through the use of cytoskeletal disruption agents.