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Ujjawal H. Gandhi
Researcher at Vanderbilt University Medical Center
Publications - 23
Citations - 971
Ujjawal H. Gandhi is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Leukemia & Population. The author has an hindex of 11, co-authored 22 publications receiving 687 citations. Previous affiliations of Ujjawal H. Gandhi include Vanderbilt University & Foundation University, Islamabad.
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Journal ArticleDOI
Outcomes of patients with multiple myeloma refractory to CD38-targeted monoclonal antibody therapy.
Ujjawal H. Gandhi,Robert F. Cornell,Arjun Lakshman,Zhubin Gahvari,Elizabeth McGehee,Megan Jagosky,Ridhi Gupta,William Varnado,Mark A. Fiala,Saurabh Chhabra,Ehsan Malek,Joshua Mansour,Barry Paul,Alyssa Barnstead,Saranya Kodali,Amarendra K. Neppalli,Michaela Liedtke,Swapna Narayana,Kelly N. Godby,Yubin Kang,Ankit Kansagra,Elvira Umyarova,Emma C. Scott,Parameswaran Hari,Ravi Vij,Saad Z. Usmani,Natalie S. Callander,Shaji Kumar,Luciano J. Costa +28 more
TL;DR: Patients with MM refractory to CD38 MoAB have poor prognosis and this study provides benchmark for new therapies to be tested in this population.
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Selenoprotein-dependent Up-regulation of Hematopoietic Prostaglandin D2 Synthase in Macrophages Is Mediated through the Activation of Peroxisome Proliferator-activated Receptor (PPAR) γ
Ujjawal H. Gandhi,Naveen Kaushal,Kodihalli C. Ravindra,Shailaja Hegde,Shakira M. Nelson,Vivek Narayan,Hema Vunta,Robert F. Paulson,K. Sandeep Prabhu +8 more
TL;DR: The results suggest the importance of selenium in the shunting of AA metabolism toward the production of PGD2 metabolites, which may have clinical implications.
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Clinical Implications of Targeting XPO1-mediated Nuclear Export in Multiple Myeloma
Ujjawal H. Gandhi,William Senapedis,Erkan Baloglu,Thaddeus J. Unger,Ajai Chari,Dan T. Vogl,Robert F. Cornell +6 more
TL;DR: The available data on the molecular implications of XPO1 inhibition in MM is reviewed and the pertinent early phase clinical data with SINE compounds are reviewed to discuss management strategies for common toxicities encountered with use of selinexor.
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Thioredoxin Reductase-1 Negatively Regulates HIV-1 Transactivating Protein Tat-dependent Transcription in Human Macrophages
Parisa Kalantari,Vivek Narayan,Sathish Kumar Natarajan,Kambadur Muralidhar,Ujjawal H. Gandhi,Hema Vunta,Andrew J. Henderson,K. Sandeep Prabhu +7 more
TL;DR: In this paper, the authors demonstrate that thioredoxin reductase-1 (TR1), a selenium-containing pyridine nucleotide-disulfide oxidoreductase that reduces protein disulfides to free thiols, negatively regulates the activity of the HIV-1 encoded transcriptional activator, Tat.
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Δ12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
Shailaja Hegde,Naveen Kaushal,Kodihalli C. Ravindra,Christopher R. Chiaro,Kelsey T. Hafer,Ujjawal H. Gandhi,Jerry T. Thompson,John P. Vanden Heuvel,Mary J. Kennett,Pamela A. Hankey,Robert F. Paulson,K. Sandeep Prabhu +11 more
TL;DR: IP administration of Δ(12)-PGJ(3) to mice infected with Friend erythroleukemia virus or those expressing the chronic myelogenous leukemia oncoprotein BCR-ABL in the hematopoietic stem cell pool completely restored normal hematologic parameters, splenic histology, and enhanced survival.