K
K. Sandeep Prabhu
Researcher at Pennsylvania State University
Publications - 99
Citations - 3529
K. Sandeep Prabhu is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Inflammation & Oxidative stress. The author has an hindex of 34, co-authored 86 publications receiving 2918 citations. Previous affiliations of K. Sandeep Prabhu include Rice University.
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Journal ArticleDOI
The Anti-inflammatory Effects of Selenium Are Mediated through 15-Deoxy-Δ12,14-prostaglandin J2 in Macrophages
Hema Vunta,Faith Davis,Umamaheswari D. Palempalli,Deepa Bhat,Ryan J. Arner,Jerry T. Thompson,Devin G. Peterson,C. Channa Reddy,K. Sandeep Prabhu +8 more
TL;DR: Modification of protein thiols by 15d-PGJ2 represents a previously undescribed code for redox regulation of gene expression by selenium, and suggests thatSelenium supplementation increases the production of 15d, PGJ2 as an adaptive response to protect cells against oxidative stress-induced pro-inflammatory gene expression.
Journal ArticleDOI
Selenoprotein Gene Nomenclature
Vadim N. Gladyshev,Vadim N. Gladyshev,Elias S.J. Arnér,Marla J. Berry,Regina Brigelius-Flohé,Elspeth A. Bruford,Raymond F. Burk,Bradley A. Carlson,Sergi Castellano,Laurent Chavatte,Marcus Conrad,Paul R. Copeland,Alan M. Diamond,Donna M. Driscoll,Ana Ferreiro,Leopold Flohé,Leopold Flohé,Fiona R. Green,Roderic Guigó,Diane E. Handy,Dolph L. Hatfield,John E. Hesketh,Peter R. Hoffmann,Arne Holmgren,Robert J. Hondal,Michael T. Howard,Kaixun Huang,Hwa-Young Kim,Ick Young Kim,Josef Köhrle,Alain Krol,Gregory V. Kryukov,Byeong Jae Lee,Byung Cheon Lee,Xin Gen Lei,Qiong Liu,Alain Lescure,Alexei V. Lobanov,Joseph Loscalzo,Matilde Maiorino,Marco Mariotti,K. Sandeep Prabhu,Margaret P. Rayman,Sharon Rozovsky,Gustavo Salinas,Edward E. Schmidt,Lutz Schomburg,Ulrich Schweizer,Miljan Simonović,Roger A. Sunde,Petra A. Tsuji,Susan Tweedie,Fulvio Ursini,Philip D. Whanger,Yan Zhang +54 more
TL;DR: The solution is to use the root symbol SELENO followed by a letter, approved by the HUGO Gene Nomenclature Committee, which resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable toselenoproteins across vertebrates.
Journal ArticleDOI
Selenium deficiency increases the expression of inducible nitric oxide synthase in RAW 264.7 macrophages: role of nuclear factor-κB in up-regulation
K. Sandeep Prabhu,Faith Zamamiri-Davis,Jennifer B Stewart,Jerry T. Thompson,Lorraine M. Sordillo,C. Channa Reddy +5 more
TL;DR: An inverse relationship between cellular Se status and iNOS expression in LPS-stimulated RAW 264.7 cells is suggested and evidence for the beneficial effects of dietary Se supplementation in the prevention and/or treatment of oxidative-stress-mediated inflammatory diseases is provided.
Journal ArticleDOI
Selenium attenuates pro-inflammatory gene expression in macrophages
Hema Vunta,Benjamin J. Belda,Ryan J. Arner,C. Channa Reddy,John P. Vanden Heuvel,K. Sandeep Prabhu +5 more
TL;DR: The results indicate that Se plays an important role as an anti-inflammatory agent by tightly regulating the expression of pro-inflammatory genes in immune cells.
Journal ArticleDOI
Is Selenium a Potential Treatment for Cancer Metastasis
TL;DR: The current knowledge about Se compounds and selenoproteins, and their effects on the development of metastasis are presented, with an emphasis on cell migration, invasion, and angiogenesis.