Ulla G. Sidelmann

TL;DR: The role that metabonomics has in the evaluation of xenobiotic toxicity studies is presented here and an evaluation of intersite NMR analytical reproducibility has revealed a high degree of robustness.

TL;DR: A series of small molecules known as ago-allosteric modulators selective for the human GLP-1 receptor are discovered, which act as both allosteric activators of the receptor and independent agonists.

TL;DR: An important role for both CYP3A4 and CYP2C8 in the human in vitro biotransformation of repaglinide is confirmed, which may have consequences for the clinical pharmacokinetics and drug-drug interactions involving repaglinside if one CYP pathway has sufficient capacity to compensate if the other is inhibited.

TL;DR: Mapping metabotypic QTLs provides a practical approach to understanding genome-phenotype relationships in mammals and may uncover deeper biological complexity, as extended genome perturbations that affect disease processes through transgenomic effects may influence QTL detection.

TL;DR: Directly coupled HPLC-NMR and its application to drug metabolism was discussed in this paper, where the authors present a comparison of the two types of NMR-based methods.