H
Hector C. Keun
Researcher at Imperial College London
Publications - 170
Citations - 10505
Hector C. Keun is an academic researcher from Imperial College London. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 50, co-authored 155 publications receiving 9093 citations. Previous affiliations of Hector C. Keun include Bristol-Myers Squibb.
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Journal ArticleDOI
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts.
Olaf Beckonert,Hector C. Keun,Timothy M. D. Ebbels,Jacob G. Bundy,Elaine Holmes,John C. Lindon,Jeremy K. Nicholson +6 more
TL;DR: The main NMR spectroscopic applications in modern metabolic research are summarized, and detailed protocols for biofluid and tissue sample collection and preparation are provided, including the extraction of polar and lipophilic metabolites from tissues.
Journal ArticleDOI
Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.
John C. Lindon,Jeremy K. Nicholson,Elaine Holmes,Henrik Antti,Mary E. Bollard,Hector C. Keun,Olaf Beckonert,Timothy M. D. Ebbels,Michael D. Reily,Donald G. Robertson,Gregory J. Stevens,Peter Luke,Alan P. Breau,Glenn H. Cantor,Roy H. Bible,Urs Niederhauser,Hans Senn,Goetz Schlotterbeck,Ulla G. Sidelmann,Steen Møller Laursen,Adrienne A. Tymiak,Bruce D. Car,Lois D. Lehman-McKeeman,Jean-Marie Colet,Ali Loukaci,Craig E. Thomas +25 more
TL;DR: The role that metabonomics has in the evaluation of xenobiotic toxicity studies is presented here and an evaluation of intersite NMR analytical reproducibility has revealed a high degree of robustness.
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High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues
Olaf Beckonert,Muireann Coen,Hector C. Keun,Yulan Wang,Timothy M. D. Ebbels,Elaine Holmes,John C. Lindon,Jeremy K. Nicholson +7 more
TL;DR: This protocol details the analysis of intact tissue samples by means of high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy and provides a detailed description of sample collection, preparation and analysis.
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Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA
TL;DR: A web tool 'IMPaLA' is presented for the joint pathway analysis of transcriptomics or proteomics and metabolomics data and performs over-representation or enrichment analysis with user-specified lists of metabolites and genes using over 3000 pre-annotated pathways from 11 databases.
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The Human Early-Life Exposome (HELIX): Project Rationale and Design
Martine Vrijheid,Rémy Slama,Oliver Robinson,Leda Chatzi,Muireann Coen,Peter van den Hazel,Cathrine Thomsen,John Wright,Toby J. Athersuch,Narcis Avellana,Xavier Basagaña,Céline Brochot,Luca Bucchini,Mariona Bustamante,Angel Carracedo,Maribel Casas,Xavier Estivill,Lesley Fairley,Diana van Gent,Juan R. González,Berit Granum,Regina Gražulevičienė,Kristine B. Gutzkow,Jordi Julvez,Hector C. Keun,Manolis Kogevinas,Rosemary R. C. McEachan,Helle Margrete Meltzer,Eduard Sabidó,Per E. Schwarze,Valérie Siroux,Jordi Sunyer,Elizabeth J. Want,Florence Anna Zeman,Mark J. Nieuwenhuijsen +34 more
TL;DR: HELIX is one of the first attempts to describe the early-life exposome of European populations and unravel its relation to omics markers and health in childhood, and will form an important first step toward the life-course exposomes.