T
Tao Wang
Researcher at Johns Hopkins University School of Medicine
Publications - 8
Citations - 1736
Tao Wang is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Nicotinamide phosphoribosyltransferase & Nicotinamide mononucleotide. The author has an hindex of 6, co-authored 8 publications receiving 1569 citations. Previous affiliations of Tao Wang include Vaccine Research Center.
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Journal ArticleDOI
Nampt/PBEF/visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme
Javier R. Revollo,Antje Körner,Kathryn F. Mills,Akiko Satoh,Tao Wang,Antje Garten,Biplab Dasgupta,Yo Sasaki,Cynthia Wolberger,Raymond R. Townsend,Jeffrey Milbrandt,Wieland Kiess,Shin-ichiro Imai +12 more
TL;DR: It is shown that eNampt does not exert insulin-mimetic effects in vitro or in vivo but rather exhibits robust NAD biosynthetic activity, suggesting a vital framework for the regulation of glucose homeostasis.
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Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme.
TL;DR: The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.
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The mechanism of OTUB1-mediated inhibition of ubiquitination.
TL;DR: Structural and biochemical studies elucidating how OTUB1 inhibits UBC13 and other E2 enzymes in a non-catalytic manner are described, and free ubiquitin is unexpectedly found to be allosterically regulated by free Ubiquitin.
Journal ArticleDOI
Extracellular Nampt Promotes Macrophage Survival via a Nonenzymatic Interleukin-6/STAT3 Signaling Mechanism
Yankun Li,Yuan Zhang,Bernhard Dorweiler,Bernhard Dorweiler,Dongying Cui,Tao Wang,Connie W.H. Woo,Cynthia S. Brunkan,Cynthia Wolberger,Shin-ichiro Imai,Ira Tabas +10 more
TL;DR: ENampt protects macrophages from ER stress-induced apoptosis by activating an IL-6/STAT3 signaling pathway via a nonenzymatic mechanism, which suggests a novel action and mechanism of eNamPT that could affect the balance of macrophage survival and death in the setting of obesity, which in turn could play important roles in obesity-associated diseases.
Journal ArticleDOI
Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia.
Valentina Audrito,Sara Serra,Davide Brusa,Francesca Mazzola,Francesca Arruga,Tiziana Vaisitti,Marta Coscia,Rossana Maffei,Davide Rossi,Tao Wang,Giorgio Inghirami,Giorgio Inghirami,Giorgio Inghirami,Menico Rizzi,Gianluca Gaidano,Joe G.N. Garcia,Cynthia Wolberger,Nadia Raffaelli,Silvia Deaglio +18 more
TL;DR: It is shown that both intracellular and extracellular NAMPT levels are increased in cells and plasma of chronic lymphocytic leukemia (CLL) patients, revealing that eNAMPT is a critical element in the induction of an immunosuppressive and tumor-promoting microenvironment of CLL.