V
Valentina Minieri
Researcher at Thomas Jefferson University
Publications - 13
Citations - 343
Valentina Minieri is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Stem cell & DNA damage. The author has an hindex of 10, co-authored 13 publications receiving 298 citations. Previous affiliations of Valentina Minieri include University of Turin & University College London.
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Journal ArticleDOI
High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells.
Valentina Turinetto,Luca Orlando,Luca Orlando,Yolanda Sanchez-Ripoll,Benjamin Kumpfmueller,Michael P. Storm,Paola Porcedda,Valentina Minieri,Silvia Saviozzi,Lisa Accomasso,Elisa Cibrario Rocchietti,Kim Moorwood,Paola Circosta,Alessandro Cignetti,Melanie J. Welham,Claudia Giachino +15 more
TL;DR: It is shown that basal γH2AX levels decrease upon ESC and iPSC differentiation and increase when the cells are treated with self‐renewal‐enhancing small molecules, suggesting a novel function of H2AX that expands the knowledge of this histone variant beyond its role in DNA damage and into a new specialized biological function in mouse pluripotent stem cells.
Journal ArticleDOI
Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells
Stefano Bartesaghi,Vincenzo Graziano,Sara Galavotti,Nick V. Henriquez,Joanne Betts,Jayeta Saxena,Valentina Minieri,A Deli,Anna Karlsson,L. Miguel Martins,Melania Capasso,Pierluigi Nicotera,Sebastian Brandner,Vincenzo De Laurenzi,Paolo Salomoni +14 more
TL;DR: In this paper, the p53 tumor suppressor is genetically inactivated in a large proportion of high grade glioma (HGG) cases, which is caused by increased reactive oxygen species and associated oxidative DNA damage.
Journal ArticleDOI
Persistent DNA damage-induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells.
Valentina Minieri,Silvia Saviozzi,Giovanna Gambarotta,Marco Lo Iacono,Lisa Accomasso,Elisa Cibrario Rocchietti,Clara Gallina,Valentina Turinetto,Claudia Giachino +8 more
TL;DR: A multifaceted consequence of ActD treatment on hMSCs is disclosed that helps to preserve this stem cell pool and prevents damaged cells from undergoing neoplastic transformation, and on the other hand alters their functional effects on the surrounding tissue microenvironment in a way that might worsen their tumour‐promoting behaviour.
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Fluorescent silica nanoparticles improve optical imaging of stem cells allowing direct discrimination between live and early-stage apoptotic cells.
Lisa Accomasso,Elisa Cibrario Rocchietti,Stefania Raimondo,Federico Catalano,Gabriele Alberto,Andrea Giannitti,Valentina Minieri,Valentina Turinetto,Luca Orlando,Silvia Saviozzi,Giuseppe Caputo,Stefano Geuna,Gianmario Martra,Claudia Giachino +13 more
TL;DR: This is the first report that shows nonfunctionalized IRIS Dots can discriminate between live and early-stage apoptotic stem cells (both mesenchymal and embryonic) through a distinct external cell surface distribution.
Journal ArticleDOI
Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification.
Svetlana Petruk,Samanta A. Mariani,Marco De Dominici,Patrizia Porazzi,Valentina Minieri,Jingli Cai,Lorraine Iacovitti,Neal Flomenberg,Bruno Calabretta,Alexander Mazo +9 more
TL;DR: It is shown here that CD34+ HPCs possess a post-replicative chromatin globally devoid of the repressive histone mark H3K27me3, required for recruitment of lineage-determining transcription factors (TFs) C/EBPα, PU.1, and GATA-1 to DNA just after DNA replication upon cytokine-induced myeloid or erythroid commitment.