M
Melanie J. Welham
Researcher at University of Bath
Publications - 51
Citations - 3261
Melanie J. Welham is an academic researcher from University of Bath. The author has contributed to research in topics: Embryonic stem cell & Cellular differentiation. The author has an hindex of 28, co-authored 51 publications receiving 3136 citations.
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Journal ArticleDOI
Regulation of Embryonic Stem Cell Self-renewal by Phosphoinositide 3-Kinase-dependent Signaling
TL;DR: A previously undescribed role for phosphoinositide 3-kinases (PI3Ks) is demonstrated in regulation of murine ES cell self-renewal and inhibition of MAP-Erk kinases reverses the effects of PI3K inhibition on self-Renewal in a time- and dose-dependent manner, suggesting that the elevated ERK activity observed upon PI3k inhibition contributes to the functional response.
Journal ArticleDOI
p110δ, a novel phosphoinositide 3-kinase in leukocytes
Bart Vanhaesebroeck,Melanie J. Welham,Kei Kotani,Robert Stein,Patricia H. Warne,Marketa Zvelebil,Kyoichiro Higashi,Stefano Volinia,Julian Downward,Michael D. Waterfield +9 more
TL;DR: Different biochemical and structural features of p110δ suggest divergent functional/regulatory capacities for this PI3K, which is exclusively found in leukocytes.
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Differential Expression of Cannabinoid Receptors in the Human Colon: Cannabinoids Promote Epithelial Wound Healing
Karen L. Wright,Nicholas Rooney,Mark Feeney,Jeremy Tate,Duncan A.F. Robertson,Melanie J. Welham,Stephen G. Ward +6 more
TL;DR: CB1 receptors are expressed in normal human colon and colonic epithelium is responsive biochemically and functionally to cannabinoids, implying an immunomodulatory role that may impact on mucosal immunity.
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Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
Takashi Akasaka,Theodore Balasas,Lisa J. Russell,Keiji Sugimoto,Aneela Majid,Renata Walewska,E. Loraine Karran,David Brown,Kelvin Cain,Lana Harder,Stefan Gesk,José I. Martín-Subero,Mark G. Atherton,Monika Brüggemann,María José Calasanz,Teresa Davies,Oskar A. Haas,Anne Hagemeijer,Helena Kempski,Michel Lessard,Debra M. Lillington,Sarah Moore,Florence Nguyen-Khac,Isabelle Radford-Weiss,Claudia Schoch,Stéphanie Struski,Polly Talley,Melanie J. Welham,Helen Worley,Jonathan C. Strefford,Christine J. Harrison,Reiner Siebert,Martin J. S. Dyer +32 more
TL;DR: The findings implicate the CEBP gene family as novel oncogenes in BCP-ALL, and suggest opposing functions of CEBP dysregulation in myeloid and lymphoid leukemogenesis.
Journal ArticleDOI
Regulation of Nanog Expression by Phosphoinositide 3-Kinase-dependent Signaling in Murine Embryonic Stem Cells
Mike P. Storm,Heather K. Bone,Craig G. Beck,Pierre-Yves Bourillot,Valerie Schreiber,Teresa Damiano,Adam Nelson,Pierre Savatier,Pierre Savatier,Melanie J. Welham +9 more
TL;DR: Embryonic stem (ES) cell pluripotency is regulated by a combination of extrinsic and intrinsic factors and regulation of GSK-3 activity by PI3Ks appears to play a key role in this process.