Valeska Ormazabal

TL;DR: It can be concluded that insulin resistance in the myocardium generates damage by at least three different mechanisms: (1) signal transduction alteration, (2) impaired regulation of substrate metabolism, and (3) altered delivery of substrates to theMyocardium.

TL;DR: An overview of MSC-derived exosomes in promoting angiogenicity and of the clinical relevance in a therapeutic approach is provided.

TL;DR: In humans, the maintenance of a low daily requirement of vitamin C is attained through an efficient system for the recycling of the vitamin involving the two families of vitaminC transporters.

TL;DR: The data indicate that SVCT2 may switch between a number of states with characteristic properties, including an inactive conformation in the absence of Ca2+/Mg2+, and at least three active states can be envisioned, including a low affinity conformation at Na+ concentrations below 20 mm and two high affinity conformations at elevated Na+, whose Na+ cooperativity is modulated by ascorbic acid.

TL;DR: Placental exosomes might have a role in the changes on insulin sensitivity in normal and GDM pregnancies, and the expression of these miRNAs varied in a consistent pattern in the placenta, in circulating exosome, and in skeletal muscle in GDM.