V
Vanessa Winiger
Researcher at Columbia University
Publications - 11
Citations - 924
Vanessa Winiger is an academic researcher from Columbia University. The author has contributed to research in topics: Dopamine & Striatum. The author has an hindex of 9, co-authored 10 publications receiving 825 citations. Previous affiliations of Vanessa Winiger include University of York.
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Journal ArticleDOI
Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning.
Christoph Kellendonk,Eleanor H. Simpson,H. Jonathan Polan,Gaël Malleret,Svetlana Vronskaya,Vanessa Winiger,Holly Moore,Eric R. Kandel +7 more
TL;DR: It is found that D2R overexpression in the striatum impacts dopamine levels, rates of dopamine turnover, and activation of D1 receptors in the prefrontal cortex, measures that are critical for working memory.
Journal ArticleDOI
Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation.
Pierre Trifilieff,Bo Feng,Eneko Urizar,Vanessa Winiger,Ryan D. Ward,Kathleen M. Taylor,Diana Martinez,Diana Martinez,Holly Moore,Holly Moore,Peter D. Balsam,Peter D. Balsam,Peter D. Balsam,Eleanor H. Simpson,Eleanor H. Simpson,Jonathan A. Javitch,Jonathan A. Javitch +16 more
TL;DR: Overexpression of postsynaptic D2R in the NAc selectively increased motivation without altering consummatory behavior, the representation of the value of the reinforcer, or the capacity to use reward associated cues in flexible ways.
Journal ArticleDOI
Selective Overexpression of Dopamine D3 Receptors in the Striatum Disrupts Motivation but not Cognition
Eleanor H. Simpson,Vanessa Winiger,Dominik Biezonski,Iram Haq,Eric R. Kandel,Christoph Kellendonk +5 more
TL;DR: Overexpression of D3R overexpression in the striatum of mice does not elicit cognitive deficits but disrupts motivation, suggesting that changes in D3Rs may be involved in the negative symptoms of schizophrenia.
Journal ArticleDOI
The effects of pharmacological modulation of the serotonin 2C receptor on goal-directed behavior in mice
Matthew R. Bailey,Cait M. Williamson,Chris Mezias,Vanessa Winiger,Rae Silver,Peter D. Balsam,Peter D. Balsam,Eleanor H. Simpson,Eleanor H. Simpson +8 more
TL;DR: It is suggested that the 5-HT2C receptor warrants further attention as a novel therapeutic target for treating pathological impairments in goal-directed motivation because of its specificity of action.
Journal ArticleDOI
An Interaction between Serotonin Receptor Signaling and Dopamine Enhances Goal-Directed Vigor and Persistence in Mice.
Matthew R. Bailey,Olivia Goldman,Estefanía P. Bello,Muhammad O. Chohan,Muhammad O. Chohan,Nuri Jeong,Vanessa Winiger,Eileen Chun,Elke Schipani,Abigail Kalmbach,Abigail Kalmbach,Joseph F. Cheer,Peter D. Balsam,Peter D. Balsam,Eleanor H. Simpson,Eleanor H. Simpson +15 more
TL;DR: It is shown that the 5-HT2C-selective ligand boosts motivation by potentiating activity-dependent DA release in the dorsomedial striatum, and this information provides promise for the development of treatments for apathy.