Eleanor H. Simpson

TL;DR: It is found that D2R overexpression in the striatum impacts dopamine levels, rates of dopamine turnover, and activation of D1 receptors in the prefrontal cortex, measures that are critical for working memory.

TL;DR: It is suggested how mouse models might test ideas about the contribution of early striatal dysfunction to the cognitive symptoms of schizophrenia and how the striatum and its cortical connections are critical for complex cognition are reviewed.

TL;DR: Evidence is provided for a role of D1 receptors in the bidirectional modulation of synaptic plasticity in the medial prefrontal cortex and for the absence of this modulation in heterozygous knockout mice, which shows that a dysregulation of dopamine receptor expression levels can have dramatic effects on synaptic plasticities in the prefrontal cortex.

TL;DR: It is suggested that early D2 overexpression alters the organization of interval timing circuits and confirms that striatal D2 signaling in the adult regulates motivational process, as well as under pathological conditions such as schizophrenia and Parkinson's disease.

TL;DR: The results confirm the prominent role of COMT in regulating DA transmission in cortex but not striatum, and the reliability of [11C]NNC 112 as a marker for low DA tone as previously suggested by studies in patients with schizophrenia.