V
Vasu Chandrasekaran
Researcher at Merck & Co.
Publications - 18
Citations - 1153
Vasu Chandrasekaran is an academic researcher from Merck & Co.. The author has contributed to research in topics: Health care & Medicine. The author has an hindex of 9, co-authored 15 publications receiving 1021 citations. Previous affiliations of Vasu Chandrasekaran include Novartis & University of North Carolina at Greensboro.
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Journal ArticleDOI
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
Mark E. Kleinman,Kiyoshi Yamada,Atsunobu Takeda,Vasu Chandrasekaran,Miho Nozaki,Judit Z. Baffi,Romulo Albuquerque,S. Yamasaki,M. Itaya,Yuzhen Pan,Binoy Appukuttan,Daniel Gibbs,Zhenglin Yang,Katalin Karikó,Balamurali K. Ambati,Balamurali K. Ambati,Traci A. Wilgus,Luisa A. DiPietro,Eiji Sakurai,Kang Zhang,Justine R. Smith,Ethan Will Taylor,Jayakrishna Ambati +22 more
TL;DR: It is shown that generic siRNAs might treat angiogenic disorders that affect 8% of the world’s population, and that si RNAs might induce unanticipated vascular or immune effects.
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Innovation at the Intersection of Clinical Trials and Real-World Data Science to Advance Patient Care
Brandon D Swift,Lokesh Jain,Craig White,Vasu Chandrasekaran,Aman Bhandari,Dyfrig A. Hughes,Pravin R. Jadhav +6 more
TL;DR: A framework for linking drug development decisions with the value proposition of the drug, utilizing pharmacokinetic–pharmacodynamic–pharmacoeconomic models, is introduced.
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Predicting dementia with routine care EMR data.
Zina Ben Miled,Zina Ben Miled,Kyle Haas,Christopher M. Black,Rezaul Karim Khandker,Vasu Chandrasekaran,Richard B. Lipton,Malaz Boustani +7 more
TL;DR: In this article, the authors developed a machine learning (ML) model that can predict dementia in a general patient population from multiple health care institutions one year and three years prior to the onset of the disease without any additional monitoring or screening.
Journal ArticleDOI
Proposed structural models of human factor Va and prothrombinase
Chang Jun Lee,Ping Lin,Vasu Chandrasekaran,Robert E. Duke,Robert E. Duke,Stephen J. Everse,Lalith Perera,Lee G. Pedersen,Lee G. Pedersen +8 more
TL;DR: The prothrombinase complex consists of factor Xa, FVa, calcium ions, and phospholipid membrane, and plays a key role in the blood coagulation process.
Predicting Dementia With Routine Care EMR Data
Zina Ben Miled,Zina Ben Miled,Kyle Haas,Christopher M. Black,Rezaul Karim Khandker,Vasu Chandrasekaran,Richard B. Lipton,Malaz Boustani +7 more
TL;DR: The results show that the combined model is generalizable across multiple institutions and is able to predict dementia within one year of its onset with an accuracy of nearly 80% despite the fact that it was trained using routine care data.