Z
Zhenglin Yang
Researcher at University of Electronic Science and Technology of China
Publications - 198
Citations - 9848
Zhenglin Yang is an academic researcher from University of Electronic Science and Technology of China. The author has contributed to research in topics: Gene & Single-nucleotide polymorphism. The author has an hindex of 44, co-authored 169 publications receiving 8139 citations. Previous affiliations of Zhenglin Yang include Southwest Jiaotong University & Moran Eye Center.
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Journal ArticleDOI
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Lars G. Fritsche,Wilmar Igl,Jessica N. Cooke Bailey,Felix Grassmann,Sebanti Sengupta,Jennifer L. Bragg-Gresham,Kathryn P. Burdon,Scott J. Hebbring,Cindy Wen,Mathias Gorski,Ivana K. Kim,David Cho,Donald J. Zack,Donald J. Zack,Eric H. Souied,Hendrik P. N. Scholl,Hendrik P. N. Scholl,Elisa Bala,Kristine ELee,David J. Hunter,Rebecca J. Sardell,Paul Mitchell,Joanna E. Merriam,Valentina Cipriani,Valentina Cipriani,Joshua D. Hoffman,Tina Schick,Yara T. E. Lechanteur,Robyn H. Guymer,Matthew P. Johnson,Yingda Jiang,Chloe M. Stanton,Gabri'lle H.S. Buitendijk,Xiaowei Zhan,Xiaowei Zhan,Alan M. Kwong,Alexis Boleda,Matthew Brooks,Linn Gieser,Rinki Ratnapriya,Kari Branham,Johanna R. Foerster,John R. Heckenlively,Mohammad Othman,Brendan J. Vote,Helena Liang,Emmanuelle Souzeau,Ian L. McAllister,Timothy Isaacs,Janette Hall,Stewart Lake,David A. Mackey,David A. Mackey,David A. Mackey,Ian J. Constable,Jamie E Craig,Terrie Kitchner,Zhenglin Yang,Zhenglin Yang,Zhiguang Su,Hongrong Luo,Daniel Chen,Hong Ouyang,Ken Flagg,Danni Lin,Guanping Mao,Henry Ferreyra,Klaus Stark,Claudia N von Strachwitz,Armin Wolf,Caroline Brandl,G. Rudolph,Matthias Olden,Margaux A. Morrison,Denise J. Morgan,Matthew Schu,Jeeyun Ahn,Giuliana Silvestri,Evangelia E. Tsironi,Kyu Hyung Park,Lindsay A. Farrer,Anton Orlin,Alexander J. Brucker,Mingyao Li,Christine A. Curcio,Saddek Mohand-Sa'd,José-Alain Sahel,Isabelle Audo,Mustapha Benchaboune,Angela J. Cree,Christina A Rennie,S. V. Goverdhan,Michelle Grunin,Shira Hagbi-Levi,Peter A. Campochiaro,Nicholas Katsanis,Frank G. Holz,Frédéric Blond,Frédéric Blond,Frédéric Blond,Hél'ne Blanché,Jean Fran ois Deleuze,Robert P. Igo,Barbara Truitt,Neal S. Peachey,Neal S. Peachey,Stacy M. Meuer,Chelsea E. Myers,Emily L. Moore,Ronald Klein,Michael A. Hauser,Eric A. Postel,Monique D. Courtenay,Stephen G. Schwartz,Jaclyn L. Kovach,William K. Scott,Gerald Liew,Ava Grace Tan,Bamini Gopinath,John C. Merriam,R. Theodore Smith,R. Theodore Smith,Jane C. Khan,Jane C. Khan,Jane C. Khan,Humma Shahid,Humma Shahid,Anthony T. Moore,Anthony T. Moore,Anthony T. Moore,J Allie McGrath,Renee Laux,Milam A. Brantley,Anita Agarwal,Lebriz Ersoy,Albert Caramoy,Thomas Langmann,Nicole T.M. Saksens,Eiko Kde Jong,Carel B. Hoyng,Melinda Cain,Andrea J. Richardson,Tammy M. Martin,John Blangero,Daniel E. Weeks,Bal Dhillon,Cornelia M. van Duijn,Kimberly F. Doheny,Jane Romm,Caroline C W Klaver,Caroline Hayward,Michael B. Gorin,Michael L. Klein,Paul N. Baird,Anneke I. den Hollander,Sascha Fauser,John R. WYates,John R. WYates,John R. WYates,Rando Allikmets,Jie Jin Wang,Debra A. Schaumberg,Debra A. Schaumberg,Barbara E.K. Klein,Stephanie A. Hagstrom,Itay Chowers,Andrew J. Lotery,Thierry Léveillard,Thierry Léveillard,Thierry Léveillard,Kang Zhang,Kang Zhang,Murray H. Brilliant,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Anand Swaroop,Emily Y. Chew,Margaret A. Pericak-Vance,Margaret M. DeAngelis,Dwight Stambolian,Jonathan L. Haines,Sudha K. Iyengar,Bernhard H. F. Weber,Gon'alo R. Abecasis,Iris M. Heid +185 more
TL;DR: The results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.
Journal ArticleDOI
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
Mark E. Kleinman,Kiyoshi Yamada,Atsunobu Takeda,Vasu Chandrasekaran,Miho Nozaki,Judit Z. Baffi,Romulo Albuquerque,S. Yamasaki,M. Itaya,Yuzhen Pan,Binoy Appukuttan,Daniel Gibbs,Zhenglin Yang,Katalin Karikó,Balamurali K. Ambati,Balamurali K. Ambati,Traci A. Wilgus,Luisa A. DiPietro,Eiji Sakurai,Kang Zhang,Justine R. Smith,Ethan Will Taylor,Jayakrishna Ambati +22 more
TL;DR: It is shown that generic siRNAs might treat angiogenic disorders that affect 8% of the world’s population, and that si RNAs might induce unanticipated vascular or immune effects.
Journal ArticleDOI
A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
Zhenglin Yang,Nicola J. Camp,Hui Sun,Zongzhong Tong,Daniel Gibbs,D. Joshua Cameron,Haoyu Chen,Yu Zhao,Erik G. Pearson,Xi Li,Jeremy Chien,Andrew T. DeWan,Jennifer Harmon,Paul S. Bernstein,Viji Shridhar,Norman A. Zabriskie,Josephine Hoh,Kimberly A. Howes,Kang Zhang +18 more
TL;DR: A single-nucleotide polymorphism in the promoter region of HTRA1 is the most likely causal variant for AMD at 10q26 and is estimated to confer a population attributable risk of 49.3%.
Journal ArticleDOI
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity.
Jingyun Yang,Wei Wang,Zimin Chen,Shuaiyao Lu,Fanli Yang,Zhenfei Bi,Linlin Bao,Fei Mo,Xue Li,Yong Huang,Weiqi Hong,Yun Yang,Yuan Zhao,Fei Ye,Sheng Lin,Wei Deng,Hua Chen,Hong Lei,Ziqi Zhang,Min Luo,Hong Gao,Yue Zheng,Yanqiu Gong,Xiaohua Jiang,Yanfeng Xu,Qi Lv,Dan Li,Manni Wang,Fengdi Li,Shunyi Wang,Guanpeng Wang,Pin Yu,Yajin Qu,Li Yang,Hongxin Deng,Aiping Tong,Jiong Li,Z. H. Wang,Jinliang Yang,Guobo Shen,Zhiwei Zhao,Yuhua Li,Jingwen Luo,Hongqi Liu,Wenhai Yu,Mengli Yang,Jingwen Xu,Junbin Wang,Haiyan Li,Haixuan Wang,Dexuan Kuang,Panpan Lin,Zhengtao Hu,Wei Guo,Wei Cheng,Yanlin He,Xiangrong Song,Chong Chen,Zhihong Xue,Shaohua Yao,Lu Chen,Xuelei Ma,Siyuan Chen,Maling Gou,Weijin Huang,Youchun Wang,Changfa Fan,Zhixin Tian,Ming Shi,Fu-Sheng Wang,Lunzhi Dai,Min Wu,Gen Li,Guangyu Wang,Yong Peng,Zhiyong Qian,Canhua Huang,Johnson Y.N. Lau,Zhenglin Yang,Yuquan Wei,Xiaobo Cen,Xiaozhong Peng,Chuan Qin,Kang Zhang,Guangwen Lu,Xiawei Wei +85 more
TL;DR: It is shown that a recombinant vaccine that comprises residues 319–545 of the RBD of the spike protein induces a potent functional antibody response in immunized mice, rabbits and non-human primates as early as 7 or 14 days after the injection of a single vaccine dose.
Journal ArticleDOI
Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China.
Xin Xu,Jian Sun,Sheng Nie,Huiyuan Li,Yaozhong Kong,Min Liang,Jinlin Hou,Xianzhong Huang,Dongfeng Li,Tean Ma,Jiaqing Peng,Shikui Gao,Yong Shao,Hong Zhu,Johnson Y.N. Lau,Guangyu Wang,Chunbao Xie,Li Jiang,Ailong Huang,Zhenglin Yang,Kang Zhang,Fan Fan Hou +21 more
TL;DR: Initial results of serological surveillance in China provide valuable data for estimation of the cumulative prevalence of SARS-CoV-2 infection in the general population and whether these results are generalizable to other populations and geographic locations.