V
Verdon Taylor
Researcher at University of Basel
Publications - 113
Citations - 7227
Verdon Taylor is an academic researcher from University of Basel. The author has contributed to research in topics: Neural stem cell & Neurogenesis. The author has an hindex of 47, co-authored 103 publications receiving 6373 citations. Previous affiliations of Verdon Taylor include Max Planck Society & École Polytechnique Fédérale de Lausanne.
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Journal ArticleDOI
Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging.
Sebastian Lugert,Onur Basak,Philip Knuckles,Ute Häussler,Klaus Fabel,Magdalena Götz,Carola A. Haas,Gerd Kempermann,Verdon Taylor,Verdon Taylor,Claudio Giachino +10 more
TL;DR: Surprisingly, reduced neurogenesis correlates with a loss of active horizontal NSCs in aged mice rather than a total loss of stem cells, and the transition to a quiescent state is reversible to rejuvenate Neurogenesis in the brain.
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Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh
Rebecca Favaro,Menella Valotta,Anna Ferri,Elisa Latorre,Jessica Mariani,Claudio Giachino,Cesare Lancini,Valentina Tosetti,Sergio Ottolenghi,Verdon Taylor,Silvia K. Nicolis +10 more
TL;DR: Neural stem cells control their status, at least partly, through Sox2-dependent autocrine mechanisms, and their replication was partially rescued by the addition of SHH and was almost fully rescued by conditioned medium from normal cells.
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RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus
Oliver Ehm,Christian Göritz,Marcela Covic,Iris Schäffner,Tobias J. Schwarz,Esra Karaca,Bettina Kempkes,Elisabeth Kremmer,Frank W. Pfrieger,Lluis Espinosa,Anna Bigas,Claudio Giachino,Verdon Taylor,Jonas Frisén,D. Chichung Lie +14 more
TL;DR: The results identify RBPJκ-dependent pathways as essential regulators of adult neural stem cell maintenance and suggest that the actions of RBPjκ are, at least in part, mediated by control of Sox2 expression.
Journal ArticleDOI
α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors
S C Robins,Iain A. Stewart,D E McNay,D E McNay,Verdon Taylor,C Giachino,M Goetz,J Ninkovic,N Briancon,N Briancon,E Maratos-Flier,Jeffrey S. Flier,Jeffrey S. Flier,M V Kokoeva,M V Kokoeva,Marysia Placzek +15 more
TL;DR: The results suggest that α-tanycytes form the critical component of a hypothalamic stem cell niche, and that local fibroblast growth factor signalling governs their proliferation.
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Notch1 is required for neuronal and glial differentiation in the cerebellum.
TL;DR: Notch1 is required for both neuron and glia formation and modulates the onset of neurogenesis within the cerebellar neuroepithelium and the effects of Notch1 ablation on gliogenesis in vivo are analyzed.