V
Victor A. Canfield
Researcher at Pennsylvania State University
Publications - 57
Citations - 3494
Victor A. Canfield is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Zebrafish & Complementary DNA. The author has an hindex of 28, co-authored 56 publications receiving 3277 citations. Previous affiliations of Victor A. Canfield include Roche Institute of Molecular Biology & Yale University.
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Journal ArticleDOI
SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans
Rebecca L. Lamason,Manzoor Ali P.K. Mohideen,Manzoor Ali P.K. Mohideen,Jason R. Mest,Andrew C.C. Wong,Andrew C.C. Wong,Heather L. Norton,Michele C. Aros,Michael J. Jurynec,Xianyun Mao,Vanessa R. Humphreville,Jasper E. Humbert,Jasper E. Humbert,Soniya Sinha,Jessica L. Moore,Jessica L. Moore,Pudur Jagadeeswaran,Wei Zhao,Gang Ning,Izabela Makalowska,Paul M. McKeigue,David H. O'Donnell,Rick A. Kittles,Esteban J. Parra,N. J. Mangini,David Grunwald,Mark D. Shriver,Victor A. Canfield,Keith C. Cheng +28 more
TL;DR: It is shown that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor.
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Genetic Evidence for the Convergent Evolution of Light Skin in Europeans and East Asians
Heather L. Norton,Heather L. Norton,Rick A. Kittles,Esteban J. Parra,Paul M. McKeigue,Xianyun Mao,Keith C. Cheng,Victor A. Canfield,Daniel G. Bradley,Brian McEvoy,Mark D. Shriver +10 more
TL;DR: A case for the recent convergent evolution of a lighter pigmentation phenotype in Europeans and East Asians is supported by the testing for the presence of positive directional selection in 6 pigmentation genes using an empirical F(ST) approach and a role for MATP in determining normal skin pigmentation variation using admixture mapping methods.
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Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
An Chi,Julio C. Valencia,Zhang-Zhi Hu,Hidenori Watabe,Hiroshi Yamaguchi,N. J. Mangini,Hongzhan Huang,Victor A. Canfield,Keith C. Cheng,Feng Yang,Riichiro Abe,Shoichi Yamagishi,Jeffrey Shabanowitz,Vincent J. Hearing,Cathy H. Wu,Ettore Appella,Donald F. Hunt +16 more
TL;DR: A novel method of removing melanin that includes in-solution digestion and immobilized metal affinity chromatography (IMAC) is reported, which has allowed this work to characterize melanosome proteomes at various developmental stages by tandem mass spectrometry.
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Identification of the Mammalian Na,K-ATPase β3 Subunit *
TL;DR: Identification of the mammalian β3 subunit suggests an even greater potential for Na,K-ATPase isoenzyme diversity than previously realized.
Journal ArticleDOI
Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish
Wendy Boehmler,Sophie Obrecht-Pflumio,Victor A. Canfield,Christine Thisse,Bernard Thisse,Robert Levenson +5 more
TL;DR: The identification of dopamine receptor genes in zebra fish should allow the power of zebrafish genetics to analyze the functional properties of this important class of neurotransmitter receptors.