F
Feng Yang
Researcher at University of California, San Diego
Publications - 60
Citations - 5177
Feng Yang is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Proteomics & Proteome. The author has an hindex of 31, co-authored 54 publications receiving 4330 citations. Previous affiliations of Feng Yang include University of Virginia & Pacific Northwest National Laboratory.
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Journal ArticleDOI
Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer
Hui Zhang,Tao Liu,Zhen Zhang,Samuel H. Payne,Bai Zhang,Jason E. McDermott,Jian-Ying Zhou,Vladislav A. Petyuk,Li Chen,Debjit Ray,Shisheng Sun,Feng Yang,Lijun Chen,Jing Wang,Punit Shah,Seong Won Cha,Paul Aiyetan,Sunghee Woo,Yuan Tian,Marina A. Gritsenko,Therese R. W. Clauss,Caitlin H. Choi,Matthew E. Monroe,Stefani N. Thomas,Song Nie,Chaochao Wu,Ronald J. Moore,Kun-Hsing Yu,David L. Tabb,David Fenyö,Vineet Bafna,Yue Wang,Henry Rodriguez,Emily S. Boja,Tara Hiltke,Robert Rivers,Lori J. Sokoll,Heng Zhu,Ie Ming Shih,Leslie Cope,Akhilesh Pandey,Bing Zhang,Michael Snyder,Douglas A. Levine,Richard D. Smith,Daniel W. Chan,Karin D. Rodland,Steven A. Carr,Michael A. Gillette,Karl R. Klauser,Eric Kuhn,D. R. Mani,Philipp Mertins,Karen A. Ketchum,Ratna R. Thangudu,Shuang Cai,Mauricio Oberti,Amanda G. Paulovich,Jeffrey R. Whiteaker,Nathan Edwards,Peter B. McGarvey,Subha Madhavan,Pei Wang,Gordon Whiteley,Steven J. Skates,Forest M. White,Christopher R. Kinsinger,Mehdi Mesri,Kenna M. Shaw,Stephen E. Stein,Paul A. Rudnick,Michael Snyder,Yingming Zhao,Xian Chen,David F. Ransohoff,Andrew N. Hoofnagle,Daniel C. Liebler,Melinda E. Sanders,Zhiao Shi,Robbert J.C. Slebos,Lisa J. Zimmerman,Sherri R. Davies,Li Ding,Matthew J. Ellis,R. Reid Townsend +84 more
TL;DR: A view of how the somatic genome drives the cancer proteome and associations between protein and post-translational modification levels and clinical outcomes in HGSC is provided.
Journal ArticleDOI
Reversed‐phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells
Yuexi Wang,Feng Yang,Marina A. Gritsenko,Yingchun Wang,Therese R. W. Clauss,Tao Liu,Yufeng Shen,Matthew E. Monroe,Daniel Lopez-Ferrer,Theresa A. Reno,Ronald J. Moore,Richard L. Klemke,David G. Camp,Richard D. Smith +13 more
TL;DR: The results demonstrate that the concatenated high pH reversed‐phased strategy is an attractive alternative to strong cation exchange for two‐dimensional shotgun proteomic analysis of trypsin‐digested human MCF10A cell sample.
Journal ArticleDOI
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Philipp Mertins,Feng Yang,Tao Liu,D. R. Mani,Vladislav A. Petyuk,Michael A. Gillette,Karl R. Clauser,Jana W. Qiao,Marina A. Gritsenko,Ronald J. Moore,Douglas A. Levine,R. Reid Townsend,Petra Erdmann-Gilmore,Jacqueline E. Snider,Sherri R. Davies,Kelly V. Ruggles,David Fenyö,R. Thomas Kitchens,Shunqiang Li,Narcisco Olvera,Fanny Dao,Henry Rodriguez,Daniel W. Chan,Daniel C. Liebler,Forest M. White,Karin D. Rodland,Gordon B. Mills,Richard D. Smith,Amanda G. Paulovich,Matthew J. Ellis,Steven A. Carr +30 more
TL;DR: The demonstrated impact of pre-analytical tissue ischemia on tumor biology mandates caution in interpreting stress-pathway activation in such samples and motivates reexamination of collection protocols for phosphoprotein analysis.
Journal ArticleDOI
Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets
Joshua F. Alfaro,Cheng-Xin Gong,Matthew E. Monroe,Joshua T. Aldrich,Therese R. W. Clauss,Samuel O. Purvine,Zihao Wang,David G. Camp,Jeffrey Shabanowitz,Pamela Stanley,Gerald W. Hart,Donald F. Hunt,Feng Yang,Richard D. Smith +13 more
TL;DR: This study produced the most comprehensive O-GlcNAc proteome of mammalian brain tissue with both protein identification and O- GloverNAc site assignment, and support the proposed regulatory cross-talk between O- GlcNAcylation and phosphorylation.
Journal ArticleDOI
Saccharomyces cerevisiae Rad9 Acts as a Mec1 Adaptor to Allow Rad53 Activation
Frédéric D. Sweeney,Feng Yang,An Chi,Jeffrey Shabanowitz,Donald F. Hunt,Daniel Durocher,Daniel Durocher +6 more
TL;DR: The results indicate that Rad9 acts as a bona fide signaling adaptor that enables Rad53 phosphorylation by Mec1, the mammalian ATR homolog, and proposes that one of the critical functions of checkpoint mediators such as MDC1, 53BP1, or Brca1 is to act as PIKK adaptors during the DNA damage response.