Víctor Farré-Alins

TL;DR: These findings are the first to demonstrate the involvement of ferroptosis in rhabdomyolysis‐associated renal damage and its sensitivity to curcumin treatment andCurcumin may be a potential therapeutic approach for patients with this syndrome.

TL;DR: Contilisant (at 1 mg kg-1 i.p.) also significantly improved lipopolysaccharide-induced cognitive deficits and showed antioxidative neuroprotective effects as well as the ability to penetrate the blood-brain barrier.

TL;DR: The therapeutic effect of targeting the LPS/TLR4 signal transduction pathway is identified and it is identified that post‐reperfusion inflammation and an up‐regulation of toll‐like receptors 4 are associated with poor outcome in stroke patients.

TL;DR: Melatonin afforded maximum protection against glutamate-induced toxicity and reversed the glutamate released almost basal levels, at 10 and 30μM concentration, respectively, and it is proposed that melatonin might strongly and positively influence the outcome of brain ischemia/reperfusion.

TL;DR: In this paper, the authors explored how TLR4-induced astrocyte activation modified synapses and cerebrovascular integrity following TBI using live calcium imaging, immunofluorescence, flow cytometry, and molecular and behavioural methods.