Journal ArticleDOI
GRADE guidelines: 7. Rating the quality of evidence—inconsistency
Gordon H. Guyatt,Andrew D Oxman,Regina Kunz,James Woodcock,Jan Brozek,Mark Helfand,Pablo Alonso-Coello,Paul Glasziou,Roman Jaeschke,Elie A. Akl,Susan L Norris,Gunn Elisabeth Vist,Philipp Dahm,Vijay K Shukla,Julian P T Higgins,Yngve Falck-Ytter,Holger J. Schünemann +16 more
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TLDR
Credibility is increased if subgroup effects are based on a small number of a priori hypotheses with a specified direction; subgroup comparisons come from within rather than between studies; tests of interaction generate low P-values; and have a biological rationale.About:
This article is published in Journal of Clinical Epidemiology.The article was published on 2011-12-01. It has received 1535 citations till now.read more
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Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report
Clive Kearon,Elie A. Akl,Elie A. Akl,Joseph Ornelas,Allen J. Blaivas,David Jiménez,Henri Bounameaux,Menno V. Huisman,Christopher S. King,Timothy A. Morris,Namita Sood,Scott M. Stevens,Janine R.E. Vintch,Philip S. Wells,Scott C. Woller,Lisa K. Moores +15 more
TL;DR: Recommendations on 12 topics that were in the 9th edition of these guidelines are updated, and 3 new topics are addressed.
Journal ArticleDOI
Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis.
Derek K. Chu,Elie A. Akl,Elie A. Akl,Stephanie Duda,Karla Solo,Sally Yaacoub,Holger J. Schünemann,Holger J. Schünemann,Amena El-Harakeh,Antonio Bognanni,Tamara Lotfi,Mark Loeb,Anisa Hajizadeh,Anna Bak,Ariel Izcovich,Carlos A. Cuello-Garcia,Chen Chen,David Harris,Ewa Borowiack,Fatimah Chamseddine,Finn Schünemann,Gian Paolo Morgano,Giovanna E.U. Muti Schünemann,Guang Chen,Hong Zhao,Ignacio Neumann,Jeffrey Chan,Joanne Khabsa,Layal Hneiny,Leila Harrison,Maureen A. Smith,Nesrine Rizk,Paolo Giorgi Rossi,Pierre AbiHanna,Rayane El-Khoury,Rosa Stalteri,Tejan Baldeh,Thomas Piggott,Yuan Zhang,Zahra Saad,Assem M. Khamis,Marge Reinap +41 more
TL;DR: The optimum distance for avoiding person-to-person virus transmission is investigated and the use of face masks and eye protection to prevent transmission of viruses is assessed to investigate the effects of physical distance, face masks, and eye Protection on virus transmission in health-care and non-health-care settings.
Journal ArticleDOI
Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer
Toshiaki Watanabe,Michio Itabashi,Yasuhiro Shimada,Shinji Tanaka,Yoshinori Ito,Yoichi Ajioka,Tetsuya Hamaguchi,Ichinosuke Hyodo,Masahiro Igarashi,Hideyuki Ishida,Megumi Ishiguro,Yukihide Kanemitsu,Norihiro Kokudo,Kei Muro,Atsushi Ochiai,Masahiko Oguchi,Yasuo Ohkura,Yutaka Saito,Yoshiharu Sakai,Hideki Ueno,Takayuki Yoshino,Takahiro Fujimori,Nobuo Koinuma,Takayuki Morita,Genichi Nishimura,Yuh Sakata,Keiichi Takahashi,Hiroya Takiuchi,Osamu Tsuruta,Toshiharu Yamaguchi,Masahiro Yoshida,Naohiko Yamaguchi,Kenjiro Kotake,Kenichi Sugihara,Rectum +34 more
TL;DR: The English version of the JSCCR Guidelines 2016 is presented, which can be used as a tool for treating colorectal cancer in actual clinical practice settings and as a guide to obtaining informed consent from patients and choosing the method of treatment for each patient.
Journal ArticleDOI
GRADE guidelines: 2. Framing the question and deciding on important outcomes
Gordon H. Guyatt,Andrew D Oxman,Regina Kunz,David C. Atkins,Jan Brozek,Gunn Elisabeth Vist,Philip Alderson,Paul Glasziou,Yngve Falck-Ytter,Holger J. Schünemann +9 more
TL;DR: In considering the importance of a surrogate outcome, authors should rate the importanceof the patient-important outcome for which the surrogate is a substitute and subsequently rate down the quality of evidence for indirectness of outcome.
Journal ArticleDOI
Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies
TL;DR: Based on a meta-analysis of studies of paired liver biopsy studies, liver fibrosis progresses in patients with NAFL and NASH.
References
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Journal ArticleDOI
GRADE guidelines: 3. Rating the quality of evidence
Howard Balshem,Mark Helfand,Mark Helfand,Holger J. Schünemann,Andrew D Oxman,Regina Kunz,Jan Brozek,Gunn Elisabeth Vist,Yngve Falck-Ytter,Joerg J Meerpohl,Susan L Norris,Gordon H. Guyatt +11 more
TL;DR: The approach of GRADE to rating quality of evidence specifies four categories-high, moderate, low, and very low-that are applied to a body of evidence, not to individual studies.
Journal ArticleDOI
GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias)
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Jan Brozek,Pablo Alonso-Coello,Victor M. Montori,Elie A. Akl,Ben Djulbegovic,Yngve Falck-Ytter,Susan L Norris,John W Williams,David C. Atkins,Joerg J Meerpohl,Holger J. Schünemann +14 more
TL;DR: In the GRADE approach, randomized trials start as high-quality evidence and observational studies as low- quality evidence, but both can be rated down if most of the relevant evidence comes from studies that suffer from a high risk of bias.
Journal ArticleDOI
GRADE guidelines: 2. Framing the question and deciding on important outcomes
Gordon H. Guyatt,Andrew D Oxman,Regina Kunz,David C. Atkins,Jan Brozek,Gunn Elisabeth Vist,Philip Alderson,Paul Glasziou,Yngve Falck-Ytter,Holger J. Schünemann +9 more
TL;DR: In considering the importance of a surrogate outcome, authors should rate the importanceof the patient-important outcome for which the surrogate is a substitute and subsequently rate down the quality of evidence for indirectness of outcome.
Journal ArticleDOI
Higher vs Lower Positive End-Expiratory Pressure in Patients With Acute Lung Injury and Acute Respiratory Distress Syndrome: Systematic Review and Meta-analysis
Matthias Briel,Maureen O. Meade,Alain Mercat,Roy G. Brower,Daniel Talmor,Stephen D. Walter,Arthur S. Slutsky,Eleanor Pullenayegum,Qi Zhou,Deborah J. Cook,Laurent Brochard,Jean-Christophe Richard,Francois Lamontagne,Francois Lamontagne,Neera Bhatnagar,Thomas E. Stewart,Gordon H. Guyatt +16 more
TL;DR: Evaluating the association of higher vs lower PEEP with patient-important outcomes in adults with acute lung injury or ARDS who are receiving ventilation with low tidal volumes found that higher levels were associated with improved survival among the subgroup of patients with ARDS, but lower levels were not associated withImproved hospital survival.
Journal ArticleDOI
Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis
TL;DR: Evidence supports the use of calcium, or calcium in combination with vitamin D supplementation, in the preventive treatment of osteoporosis in people aged 50 years or older.