Vincent Dupriez

TL;DR: The pharmacology of GPR43 matches indeed the effects of SCFAs on neutrophils, in terms of intracellular Ca2+ release and chemotaxis, and might constitute a target allowing us to modulate immune responses in these pathological situations.

TL;DR: A new plate reader is validated for HTS in 96- and 384-well plates with CHO-K1 cells stably coexpressing mitochondrial apoaequorin and different GPCRs (AequoScreen cell lines) and the results bring new insights to functional assays, and therefore reinforce the interest in aequorin-based assays in a HTS environment.

TL;DR: Results indicate that both disulfide bonds of CCR5 are necessary for maintaining the structural integrity of the receptor necessary for ligand binding and signaling and Env binding and the mechanisms of HIV entry appear much less sensitive to alterations of C CR5 conformation.

TL;DR: The ppL7 and ppL8 genes encode the precursors of a class of peptide ligands, active on two receptor subtypes, GPR7 and GPR8, and suggest that each ligand and receptor has partially overlapping but also specific roles in this signaling system.

TL;DR: It is reported that the Drosophila geneCG5911 encodes two functionally distinct subtypes of G protein-coupled receptors through alternative splicing that respond preferentially to ecdysis-triggering hormones of flies and moths that are evolutionarily related to thyrotropin-releasing hormone and neuromedin U receptors.