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Natalia Giltiay
Researcher at Cleveland Clinic
Publications - 8
Citations - 1037
Natalia Giltiay is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: B-cell activating factor & Immunology. The author has an hindex of 4, co-authored 5 publications receiving 924 citations.
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Journal ArticleDOI
The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease
Youcun Qian,Caini Liu,Justin Hartupee,Cengiz Z. Altuntas,Muhammet F. Gulen,Daniel Jane-wit,Jianhua Xiao,Yi Lu,Natalia Giltiay,Jinbo Liu,Tomasz Kordula,Qi-Wei Zhang,Bruce A. Vallance,Shadi Swaidani,Mark A. Aronica,Vincent K. Tuohy,Thomas A. Hamilton,Xiaoxia Li +17 more
TL;DR: The data show that Act1 is essential in IL-17-dependent signaling in autoimmune and inflammatory disease and was associated with much less inflammatory disease in vivo in both autoimmune encephalomyelitis and dextran sodium sulfate–induced colitis.
Journal ArticleDOI
Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis
Zizhen Kang,Cengiz Z. Altuntas,Muhammet F. Gulen,Caini Liu,Natalia Giltiay,Hongwei Qin,LiPing Liu,Wen Qian,Richard M. Ransohoff,Cornelia C. Bergmann,Stephen A. Stohlman,Vincent K. Tuohy,Xiaoxia Li +12 more
TL;DR: Astroctyes are critical in IL-17-Act1-mediated leukocyte recruitment during autoimmune-induced inflammation of the CNS, and targeted Act1 deficiency in neuroectoderm-derived CNS-resident cells resulted in markedly reduced severity in EAE.
Journal ArticleDOI
Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling
Caini Liu,Wen Qian,Youcun Qian,Natalia Giltiay,Yi Lu,Shadi Swaidani,Saurav Misra,Li Deng,Zhijian J. Chen,Xiaoxia Li +9 more
TL;DR: It is proposed that Act1 mediates IL- 17–induced signaling pathways through its E3 ubiquitin ligase activity and that TRAF6 is a critical substrate of Act1, which indicates the importance of protein ubiquitination in the IL-17–dependent inflammatory response.
Journal ArticleDOI
Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome.
Youcun Qian,Natalia Giltiay,Jianhua Xiao,Jianhua Xiao,Yue Wang,Jun Tian,Shuhua Han,Martin L. Scott,Robert H. Carter,Trine N. Jørgensen,Xiaoxia Li +10 more
TL;DR: It is demonstrated that mice deficient in Act1 developed systemic autoimmune disease with histological and serological features of human Sjögren's syndrome (SS), in association with systemic lupus erythematosus‐like nephritis.