V
Vincent Kwok-Man Poon
Researcher at University of Hong Kong
Publications - 35
Citations - 3207
Vincent Kwok-Man Poon is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Virus & Viral load. The author has an hindex of 25, co-authored 35 publications receiving 2537 citations. Previous affiliations of Vincent Kwok-Man Poon include Li Ka Shing Faculty of Medicine, University of Hong Kong.
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Journal ArticleDOI
Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis
Jie Zhou,Hin Chu,Cun Li,Bosco Ho-Yin Wong,Zhongshan Cheng,Vincent Kwok-Man Poon,Tianhao Sun,Candy Choi-Yi Lau,Kenneth K. Y. Wong,Jimmy Yu Wai Chan,Jasper Fuk-Woo Chan,Kelvin K. W. To,Kwok-Hung Chan,Bo-Jian Zheng,Kwok-Yung Yuen +14 more
TL;DR: It is conclusively showed that MERS-CoV can establish a productive infection in human macrophages and the aberrant induction of inflammatory cytokines/chemokines could be important in the disease pathogenesis.
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Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus
Jie Zhou,Cun Li,Guangyu Zhao,Hin Chu,Dong Wang,Helen H.N. Yan,Vincent Kwok-Man Poon,Lei Wen,Bosco Ho-Yin Wong,Xiaoyu Zhao,Man Chun Chiu,Dong Yang,Yixin Wang,Rex Au-Yeung,Ivy Hau-Yee Chan,Shihui Sun,Jasper Fuk-Woo Chan,Kelvin K. W. To,Ziad A. Memish,Ziad A. Memish,Victor M. Corman,Christian Drosten,Ivan Hung,Yusen Zhou,Suet Yi Leung,Kwok-Yung Yuen +25 more
TL;DR: It is demonstrated that human primary intestinal epithelial cells, small intestine explants, and intestinal organoids were highly susceptible to MERS-CoV and can sustain robust viral replication and suggest that the human intestinal tract may serve as an alternative infection route for MERS -CoV.
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Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex
Kam Leung Siu,Kin-Hang Kok,Ming Him James Ng,Vincent Kwok-Man Poon,Kwok-Yung Yuen,Bo-Jian Zheng,Dong-Yan Jin +6 more
TL;DR: The findings reveal a new mechanism by which SARS coronavirus circumvents the production of type I interferons, and inhibits TBK1/IKKϵ-dependent activation of IRF3/IRF7 transcription factors.
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Differentiated human airway organoids to assess infectivity of emerging influenza virus
Jie Zhou,Cun Li,Norman Sachs,Man Chun Chiu,Bosco Ho-Yin Wong,Hin Chu,Vincent Kwok-Man Poon,Dong Wang,Xiaoyu Zhao,Lei Wen,Wenjun Song,Wenjun Song,Shuofeng Yuan,Kenneth K. Y. Wong,Jasper Fuk-Woo Chan,Kelvin K. W. To,Honglin Chen,Hans Clevers,Kwok-Yung Yuen +18 more
TL;DR: The proximal differentiated airway organoids can be utilized to predict the infectivity of influenza viruses and, more broadly, provide a universal platform for studying the biology and pathology of the human airway.
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Identification of a Receptor-Binding Domain in the S Protein of the Novel Human Coronavirus Middle East Respiratory Syndrome Coronavirus as an Essential Target for Vaccine Development
Lanying Du,Guangyu Zhao,Zhihua Kou,Cuiqing Ma,Shihui Sun,Vincent Kwok-Man Poon,Lu Lu,Lili Wang,Asim K. Debnath,Bo-Jian Zheng,Yusen Zhou,Shibo Jiang,Shibo Jiang +12 more
TL;DR: It is shown that residues 377 to 662 in the S protein of MERS-CoV specifically bound to DPP4-expressing cells and soluble DPP 4 protein and induced significant neutralizing antibody responses, suggesting that this region contains the receptor-binding domain (RBD), which has a potential to be developed as a MERS -CoV vaccine.