V
Vinodkumar B. Pillai
Researcher at University of Chicago
Publications - 41
Citations - 3935
Vinodkumar B. Pillai is an academic researcher from University of Chicago. The author has contributed to research in topics: SIRT3 & Sirtuin. The author has an hindex of 24, co-authored 40 publications receiving 3315 citations. Previous affiliations of Vinodkumar B. Pillai include Yerkes National Primate Research Center.
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Journal ArticleDOI
SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70
Nagalingam R. Sundaresan,Sadhana Samant,Vinodkumar B. Pillai,Senthilkumar B. Rajamohan,Mahesh P. Gupta +4 more
TL;DR: It is found that SIRT3 is a stress-responsive deacetylase and that its increased expression protects myocytes from genotoxic and oxidative stress-mediated cell death, and identifies Ku70 as a new target of Sirt3.
Journal ArticleDOI
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
Nagalingam R. Sundaresan,Prabhakaran Vasudevan,Lei Zhong,Gene Kim,Sadhana Samant,Vishwas Parekh,Vinodkumar B. Pillai,P. V. Ravindra,Madhu Gupta,Valluvan Jeevanandam,John M. Cunningham,Chu-Xia Deng,David B. Lombard,Raul Mostoslavsky,Mahesh P. Gupta +14 more
TL;DR: It is shown that sirtuin 6 (SIRT6), a nuclear histone deacetylase, functions at the level of chromatin to directly attenuate IGF-Akt signaling and implicate SIRT6 in the development of cardiac hypertrophy and failure.
Journal ArticleDOI
Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway
Vinodkumar B. Pillai,Nagalingam R. Sundaresan,Gene Kim,Madhu Gupta,Senthilkumar B. Rajamohan,Jyothish B. Pillai,Sadhana Samant,P. V. Ravindra,Ayman Isbatan,Mahesh P. Gupta +9 more
TL;DR: The results reveal a novel role of NAD as an inhibitor of cardiac hypertrophic signaling, and suggest that prevention of NAD depletion may be critical in the treatment of cardiac hypertrophy and heart failure.
Journal ArticleDOI
SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress
Sadhana Samant,Hannah J. Zhang,Zhigang Hong,Vinodkumar B. Pillai,Nagalingam R. Sundaresan,Donald Wolfgeher,Stephen L. Archer,Stephen L. Archer,David C. Chan,Mahesh P. Gupta +9 more
TL;DR: It is reported that OPA1, a mitochondrial fusion protein, was hyperacetylated in hearts under pathological stress and this posttranslational modification reduced the GTPase activity of the protein.
Journal ArticleDOI
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3
Vinodkumar B. Pillai,Sadhana Samant,Nagalingam R. Sundaresan,H. Raghuraman,Gene Kim,Michael Y. Bonner,Jack L. Arbiser,Douglas I. Walker,Dean P. Jones,David Gius,Mahesh P. Gupta +10 more
TL;DR: The results suggest that HKL is a pharmacological activator of SIRT3 capable of blocking, and even reversing, the cardiac hypertrophic response.