V
Vita Fedele
Researcher at Buck Institute for Research on Aging
Publications - 10
Citations - 1148
Vita Fedele is an academic researcher from Buck Institute for Research on Aging. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 8, co-authored 10 publications receiving 1105 citations. Previous affiliations of Vita Fedele include University of California, San Francisco & Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies
Michael D. Mattie,Christopher C. Benz,Jessica Bowers,Kelly Sensinger,Linda Wong,Gary K. Scott,Vita Fedele,David G. Ginzinger,Robert Getts,Christopher M. Haqq +9 more
TL;DR: Findings demonstrate that optimized high-throughput microRNA expression profiling offers novel biomarker identification from typically small clinical samples such as breast and prostate cancer biopsies.
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Cytoskeleton and paclitaxel sensitivity in breast cancer: The role of β-tubulins
Stefania Tommasi,Anita Mangia,Rosanna Lacalamita,Antonia Bellizzi,Vita Fedele,Annalisa Chiriatti,Christopher Thomssen,Nancy Kendzierski,A Latorre,Vito Lorusso,Francesco Schittulli,Francesco Alfredo Zito,Maria Kavallaris,Angelo Paradiso +13 more
TL;DR: It is suggested that Class III β‐tubulin tumor expression could be considered a predictive biomarker of paclitaxel‐clinical resistance for breast cancer patients and Antisense oligonucleotide (ODN) experiments confirmed that the inhibition of Class IIIβ‐ Tubulin could at least partially increase paclitxel‐chemosensitivity.
Journal ArticleDOI
Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers
Christina Yau,Vita Fedele,Ritu Roydasgupta,Jane Fridlyand,Alan Hubbard,Joe W. Gray,Karen Chew,Shanaz Dairkee,Dan H. Moore,Francesco Schittulli,Stefania Tommasi,Angelo Paradiso,Donna G. Albertson,Christopher C. Benz +13 more
TL;DR: In this paper, the authors show that epigenetic transcriptome changes, more than genotypic variation, account for age-associated differences in sporadic breast cancer incidence and prognosis.
Journal Article
Aging Impacts Transcriptome but not Genome of Hormone-dependent Breast Cancers
Christina Yau,Vita Fedele,Ritu Roydasgupta,Jane Fridlyand,Alan Hubbard,Joe W. Gray,Karen Chew,Shanaz H. Dairkee,Dan H. Moore,Francesco Schittulli,Stefania Tommasi,Angelo Paradiso,Donna G. Albertson,Christopher C. Benz +13 more
TL;DR: It is suggested that epigenetic transcriptome changes, more than genotypic variation, account for age-associated differences in sporadic breast cancer incidence and prognosis.
Journal ArticleDOI
655Val and 1170Pro ERBB2 SNPs in Familial Breast Cancer Risk and BRCA1 Alterations
Stefania Tommasi,Vita Fedele,Rosanna Lacalamita,M. Bruno,Francesco Schittulli,David G. Ginzinger,Gery Scott,Serenella Eppenberger-Castori,Daniele Calistri,Silvia Casadei,Ian Seymour,S. Longo,Gianluigi Giannelli,Brunella Pilato,Giovanni Simone,Christopher C. Benz,Angelo Paradiso +16 more
TL;DR: Findings point to the existence of an association of ERBB2 allelic variants at both loci with specific breast tumor phenotypes and to the need of deeply investigate different gene SNPs association for risk defining.