V
Vivien Platt
Researcher at University of Liverpool
Publications - 5
Citations - 968
Vivien Platt is an academic researcher from University of Liverpool. The author has contributed to research in topics: Regulation of gene expression & Human leukocyte antigen. The author has an hindex of 4, co-authored 5 publications receiving 901 citations.
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Journal ArticleDOI
Circulating microRNAs as potential markers of human drug‐induced liver injury
Philip J. Starkey Lewis,James W. Dear,Vivien Platt,Kenneth J. Simpson,Darren G. Craig,Daniel J. Antoine,Neil French,Neeraj Dhaun,David J. Webb,Eithne Costello,John P. Neoptolemos,Jonathan G. Moggs,Christopher E. Goldring,B. Kevin Park +13 more
TL;DR: This work provides the first evidence for the potential use of miRNAs as biomarkers of human drug‐induced liver injury by examining these molecules, for the first time, in humans with APAP poisoning.
Journal ArticleDOI
Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital.
Daniel J. Antoine,James W. Dear,Philip J. Starkey Lewis,Vivien Platt,Judy Coyle,Moyra Masson,Ruben Thanacoody,Alasdair Gray,David J. Webb,Jonathan G. Moggs,D. Nicholas Bateman,Christopher E. Goldring,B. Kevin Park +12 more
TL;DR: Elevations in plasma miR‐122, HMGB1, and necrosis K18 identified subsequent ALI development in patients on admission to the hospital, soon after acetaminophen overdose, and in patients with ALTs in the normal range.
Journal ArticleDOI
In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers.
Ana Alfirevic,Faviel F. Gonzalez-Galarza,Catherine C. Bell,Klara Martinsson,Klara Martinsson,Vivien Platt,Giovanna Bretland,Jane Evely,Maike Lichtenfels,Karin Cederbrant,Neil French,Dean J. Naisbitt,B. Kevin Park,Andrew R. Jones,Munir Pirmohamed +14 more
TL;DR: The authors' bioinformatic analysis indicates that there may be a connection between the different HLA alleles associated with DILI caused by therapeutically and structurally different drugs, possibly through peptide binding of one of the HLA allele that defines the causal haplotype.
Journal ArticleDOI
Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.
Cliff Rowe,Christopher E. Goldring,Neil R. Kitteringham,Rosalind E. Jenkins,Brian S Lane,Christopher M. Sanderson,Victoria Elliott,Vivien Platt,Peter Metcalfe,B. Kevin Park +9 more
TL;DR: These experiments provide a detailed proteomics data set to direct further work into maintaining hepatic phenotype using cultured primary hepatocytes and stem cell derived hepatocyte-like cells.
Journal ArticleDOI
Mechanistic biomarkers provide early and sensitive detection of paracetamol-induced acute liver injury at first presentation to hospital
James W. Dear,Daniel J. Antoine,Philip J. Starkey Lewis,Vivien Platt,Judy Coyle,Moyra Masson,Ruben Thanacoody,Alasdair Gray,David J. Webb,Jonathan G. Moggs,D. Nicholas Bateman,Christopher E. Goldring,Kevin Park +12 more