P
Philip J. Starkey Lewis
Researcher at University of Edinburgh
Publications - 33
Citations - 1739
Philip J. Starkey Lewis is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Hepatocyte & Liver regeneration. The author has an hindex of 16, co-authored 30 publications receiving 1340 citations. Previous affiliations of Philip J. Starkey Lewis include University of Liverpool & Medical Research Council.
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Journal ArticleDOI
Circulating microRNAs as potential markers of human drug‐induced liver injury
Philip J. Starkey Lewis,James W. Dear,Vivien Platt,Kenneth J. Simpson,Darren G. Craig,Daniel J. Antoine,Neil French,Neeraj Dhaun,David J. Webb,Eithne Costello,John P. Neoptolemos,Jonathan G. Moggs,Christopher E. Goldring,B. Kevin Park +13 more
TL;DR: This work provides the first evidence for the potential use of miRNAs as biomarkers of human drug‐induced liver injury by examining these molecules, for the first time, in humans with APAP poisoning.
Journal ArticleDOI
Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital.
Daniel J. Antoine,James W. Dear,Philip J. Starkey Lewis,Vivien Platt,Judy Coyle,Moyra Masson,Ruben Thanacoody,Alasdair Gray,David J. Webb,Jonathan G. Moggs,D. Nicholas Bateman,Christopher E. Goldring,B. Kevin Park +12 more
TL;DR: Elevations in plasma miR‐122, HMGB1, and necrosis K18 identified subsequent ALI development in patients on admission to the hospital, soon after acetaminophen overdose, and in patients with ALTs in the normal range.
Journal ArticleDOI
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.
Sofia Ferreira-Gonzalez,Wei-Yu Lu,Alexander Raven,Benjamin J. Dwyer,Tak Yung Man,Eoghan O'Duibhir,Philip J. Starkey Lewis,Lara Campana,Timothy J. Kendall,Thomas G. Bird,Núria Tarrats,Juan Carlos Acosta,Luke Boulter,Stuart J. Forbes +13 more
TL;DR: A mouse model of biliary senescence is developed based on the conditional deletion of Mdm2 in bile ducts and it is shown that inhibiting TGFβ limits senescences-dependent aggravation of cholangiopathies.
Journal ArticleDOI
Mesenchymal Stem Cells and Induced Bone Marrow‐Derived Macrophages Synergistically Improve Liver Fibrosis in Mice
Yusuke Watanabe,Atsunori Tsuchiya,Satoshi Seino,Yuzo Kawata,Yuichi Kojima,Shunzo Ikarashi,Philip J. Starkey Lewis,Wei-Yu Lu,Junichi Kikuta,Hirokazu Kawai,Satoshi Yamagiwa,Stuart J. Forbes,Masaru Ishii,Shuji Terai +13 more
TL;DR: A novel therapeutic approach for cirrhosis using mesenchymal stem cells (MSCs) and colony‐stimulating factor‐1‐induced bone marrow‐derived macrophages (id‐BMMs) is described and the mechanisms underlying fibrosis improvement and regeneration are analyzed.
Journal ArticleDOI
Alternatively activated macrophages promote resolution of necrosis following acute liver injury
Philip J. Starkey Lewis,Philip J. Starkey Lewis,Lara Campana,Niya Aleksieva,Jennifer A Cartwright,Alison C. MacKinnon,Eoghan O'Duibhir,Timothy J. Kendall,Matthieu Vermeren,Adrian Thomson,Victoria L. Gadd,Benjamin J. Dwyer,Rhona Aird,Tak-Yung Man,Adriano G. Rossi,Lesley M. Forrester,B. Kevin Park,Stuart J. Forbes,Stuart J. Forbes +18 more
TL;DR: Whether macrophages, an injury-responsive leukocyte that can scavenge dead/dying cells, could serve as a cell-based therapy in an experimental model of acetaminophen overdose was tested and it was identified that AAMs have value as a Cell-based Therapy in an Experimental model of APAP-ALI.