D
David J. Webb
Researcher at University of Edinburgh
Publications - 583
Citations - 38260
David J. Webb is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Endothelin receptor & Blood pressure. The author has an hindex of 97, co-authored 568 publications receiving 35432 citations. Previous affiliations of David J. Webb include Queen's University & Hammersmith Hospital.
Papers
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Journal ArticleDOI
Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects
Yoav Ben-Shlomo,Melissa Spears,Chris Boustred,Margaret T May,Simon G. Anderson,Emelia J. Benjamin,Pierre Boutouyrie,James D. Cameron,Chen Huan Chen,J. Kennedy Cruickshank,Shih-Jen Hwang,Edward G. Lakatta,Stéphane Laurent,João Maldonado,Gary F. Mitchell,Samer S. Najjar,Anne B. Newman,Mitsuru Ohishi,Bruno Pannier,Telmo Pereira,Ramachandran S. Vasan,Tomoki Shokawa,Kim Sutton-Tyrell,Francis Verbeke,Kang Ling Wang,David J. Webb,Tine W. Hansen,Sophia Zoungas,Carmel M. McEniery,John R. Cockcroft,Ian B. Wilkinson +30 more
TL;DR: In this paper, aortic pulse wave velocity (aPWV) improves prediction of cardiovascular disease (CVD) events beyond conventional risk factors, but they have been underpowered to examine whether this is true for different subgroups.
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The influence of heart rate on augmentation index and central arterial pressure in humans
TL;DR: An inverse, linear relationship between AIx is demonstrated, likely due to alterations in the timing of the reflected pressure wave, produced by changes in the absolute duration of systole, which may explain the lack of rise in central systolic pressure during incremental pacing despite an increase in peripheral pressure.
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Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis
Ian B. Wilkinson,Sabine A. Fuchs,Ilse M. Jansen,James C. Spratt,Gordon D Murray,John R. Cockcroft,David J. Webb +6 more
TL;DR: PWA is a simple and reproducible technique with which to measure PWV and AIx and may, therefore, be suitable for large-scale population and intervention studies investigating the clinical relevance of vascular stiffness.
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Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial
Bryan Williams,Thomas M. MacDonald,Steve Morant,David J. Webb,Peter S. Sever,Gordon T. McInnes,Ian Ford,J. Kennedy Cruickshank,Mark J. Caulfield,Jackie Salsbury,Isla S. Mackenzie,Sandosh Padmanabhan,Morris J. Brown +12 more
TL;DR: Spironolactone was the most effective blood pressure-lowering treatment, throughout the distribution of baseline plasma renin; but its margin of superiority and likelihood of being the best drug for the individual patient were many-fold greater in the lower than higher ends of the distribution.
Journal ArticleDOI
Noninvasive Assessment of Arterial Stiffness and Risk of Atherosclerotic Events
James Oliver,David J. Webb +1 more
TL;DR: The effects of current and future cardiovascular drugs on arterial stiffness are discussed, as is the relationship between arterial elasticity and endothelial function.