Joshua M. Farber

TL;DR: In this paper, the chemokine receptors CXCR4 and CCR5, members of the G protein-coupled receptor superfamily, have been identified as the principal coreceptors for T cell line-tropic and macrophagetropic HIV-1 isolates, respectively.

TL;DR: It is demonstrated that murine β-defensin 2 (mDF2β) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and d endritic cell maturation, suggesting that mDF2 β may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigENS.

TL;DR: RHuMig and rIP‐10 share additional activities, including inhibition of neovascularization, inhibition of hematopoietic progenitor cells, and anti‐tumor effects, and that, despite their similar activities assayed in vitro, Mig and IP‐10/Crg‐2 may serve non‐redundant functions in vivo.

TL;DR: This work reviews this extended family of chemokine receptors and Chemokine-binding proteins at the basic, translational, and clinical levels, including an update on drug development and introduces a new nomenclature for atypical chemokin receptors with the stem ACKR (atypicalChemokine receptor).

TL;DR: In this article, the authors reported that IP-10 is a potent inhibitor of angiogenesis in vivo and showed that it significantly inhibited basic fibroblast growth factor-induced neovascularization of Matrigel.