M
Markus Krumbholz
Researcher at University of Tübingen
Publications - 83
Citations - 8606
Markus Krumbholz is an academic researcher from University of Tübingen. The author has contributed to research in topics: Multiple sclerosis & Natalizumab. The author has an hindex of 39, co-authored 77 publications receiving 7364 citations. Previous affiliations of Markus Krumbholz include University of Rostock & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Netting neutrophils in autoimmune small-vessel vasculitis.
Kai Kessenbrock,Markus Krumbholz,Ulf Schönermarck,Walter Back,Wolfgang Gross,Zena Werb,Hermann-Josef Gröne,Volker Brinkmann,Dieter E. Jenne +8 more
TL;DR: It is shown that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 and myeloperoxidase (MPO).
Journal ArticleDOI
MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47
Andreas Junker,Markus Krumbholz,S. Eisele,Hema Mohan,Florian Augstein,Robert Bittner,Hans Lassmann,Hartmut Wekerle,Reinhard Hohlfeld,Edgar Meinl +9 more
TL;DR: It is suggested that microRNA dysregulated in multiple sclerosis lesions reduce CD47 in brain resident cells, releasing macrophages from inhibitory control, thereby promoting phagocytosis of myelin and have broad implications for microRNA-regulated macrophage activation in inflammatory diseases.
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Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment.
Markus Krumbholz,Diethilde Theil,Sabine Cepok,Bernhard Hemmer,Pia Kivisäkk,Richard M. Ransohoff,Monika Hofbauer,Cinthia Farina,Tobias Derfuss,Caroline Hartle,Jia Newcombe,Reinhard Hohlfeld,Edgar Meinl +12 more
TL;DR: The strong linkage of CXCL13 to immune cells and immunoglobulin levels in CSF suggests that this is one of the factors that attract and maintain B and T cells in inflamed CNS lesions.
Journal ArticleDOI
BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma
Markus Krumbholz,Diethilde Theil,Tobias Derfuss,Andreas Rosenwald,Frank Schrader,Camelia-Maria Monoranu,Susan L. Kalled,Donna M. Hess,Barbara Serafini,Francesca Aloisi,Hartmut Wekerle,Reinhard Hohlfeld,Edgar Meinl +12 more
TL;DR: Astrocytes is identified as a nonimmune source of B cell–activating factor of the tumor necrosis factor family and CNS-produced BAFF may support B cell survival in inflammatory diseases and primary B cell lymphoma.
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Neuromyelitis optica: Evaluation of 871 attacks and 1,153 treatment courses.
Ingo Kleiter,Anna Gahlen,Nadja Borisow,Katrin Fischer,Klaus-Dieter Wernecke,Brigitte Wegner,Kerstin Hellwig,Florence Pache,Klemens Ruprecht,Joachim Havla,Markus Krumbholz,Tania Kümpfel,Orhan Aktas,Hans-Peter Hartung,Marius Ringelstein,Christian Geis,Christoph Kleinschnitz,Achim Berthele,Bernhard Hemmer,Klemens Angstwurm,Jan-Patrick Stellmann,Simon Schuster,Martin Stangel,Florian Lauda,Hayrettin Tumani,Christoph Mayer,Lena Zeltner,Ulf Ziemann,Ralf A. Linker,Matthias Schwab,Martin Marziniak,Florian Then Bergh,Ulrich Hofstadt-van Oy,Oliver Neuhaus,Alexander Winkelmann,Wael Marouf,Jürgen H. Faiss,Brigitte Wildemann,Friedemann Paul,Sven Jarius,Corinna Trebst +40 more
TL;DR: The frequency, sequence, and efficacy of therapies used for NMO attacks are analyzed and it is shown that certain therapies are more effective than others in cases of severe N MO attacks.