V
Volker Eckstein
Researcher at Heidelberg University
Publications - 92
Citations - 6934
Volker Eckstein is an academic researcher from Heidelberg University. The author has contributed to research in topics: CD34 & Haematopoiesis. The author has an hindex of 36, co-authored 88 publications receiving 6353 citations. Previous affiliations of Volker Eckstein include University Hospital Heidelberg.
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Journal ArticleDOI
Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood.
Wolfgang Wagner,Frederik Wein,Anja Seckinger,Maria Frankhauser,Ute Wirkner,Ulf Krause,Jonathon Blake,Christian Schwager,Volker Eckstein,Wilhelm Ansorge,Anthony D. Ho +10 more
TL;DR: The results have provided a foundation for a more reproducible and reliable quality control using genotypic analysis for defining MSC.
Journal ArticleDOI
Replicative senescence of mesenchymal stem cells: a continuous and organized process.
Wolfgang Wagner,Patrick Horn,Mirco Castoldi,Anke Diehlmann,Simone Bork,Rainer Saffrich,Vladimir Benes,Jonathon Blake,Stefan M. Pfister,Volker Eckstein,Anthony D. Ho +10 more
TL;DR: The studies indicate that replicative senescence of MSC preparations is a continuous process starting from the first passage onwards, which includes far reaching alterations in phenotype, differentiation potential, global gene expression patterns, and miRNA profiles that need to be considered for therapeutic application of M SC preparations.
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Aging and replicative senescence have related effects on human stem and progenitor cells.
Wolfgang Wagner,Wolfgang Wagner,Simone Bork,Patrick Horn,Damir Krunic,Thomas Walenda,Anke Diehlmann,Vladimir Benes,Jonathon Blake,Franz Xaver Huber,Volker Eckstein,Petra Boukamp,Anthony D. Ho +12 more
TL;DR: It was striking that several age-related gene expression changes in both MSC and HPC were also differentially expressed upon replicative senescence of MSC in vitro, indicating that the authors' stem and progenitor cells undergo a similar process also in vivo.
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Differentiation Therapy Exerts Antitumor Effects on Stem-like Glioma Cells
Benito Campos,Feng Wan,Feng Wan,Mohammad Farhadi,Aurélie Ernst,Felix Zeppernick,Katrin E. Tagscherer,Rezvan Ahmadi,Jennifer Lohr,Christine Dictus,Georg Gdynia,Stephanie E. Combs,Violaine Goidts,Burkhard Helmke,Volker Eckstein,Wilfried Roth,Philipp Beckhove,Peter Lichter,Andreas Unterberg,Bernhard Radlwimmer,Christel Herold-Mende +20 more
TL;DR: It is shown that all-trans retinoic acid treatment alone can induce antitumor effects in vivo, and the potential of differentiation treatment to target the stem-like cell population in glioblastoma is highlighted.
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Effector T-Cell Infiltration Positively Impacts Survival of Glioblastoma Patients and Is Impaired by Tumor-Derived TGF-β
Jennifer Lohr,Thomas Ratliff,Andrea Huppertz,Yingzi Ge,Christine Dictus,Rezvan Ahmadi,Stefan Grau,Nobuyoshi Hiraoka,Volker Eckstein,Rupert C. Ecker,Thomas Korff,Andreas von Deimling,Andreas Unterberg,Philipp Beckhove,Christel Herold-Mende +14 more
TL;DR: Infiltration of all T-cell subsets increased in high-grade tumors and within pGBM, elevated numbers of intratumoral effector T cells (Teff, cytotoxic and helper) significantly correlated with a better survival; regulatory T cells were infrequently present and not associated with GBM patient outcome.