Volker Eckstein

TL;DR: The results have provided a foundation for a more reproducible and reliable quality control using genotypic analysis for defining MSC.

TL;DR: The studies indicate that replicative senescence of MSC preparations is a continuous process starting from the first passage onwards, which includes far reaching alterations in phenotype, differentiation potential, global gene expression patterns, and miRNA profiles that need to be considered for therapeutic application of M SC preparations.

TL;DR: It was striking that several age-related gene expression changes in both MSC and HPC were also differentially expressed upon replicative senescence of MSC in vitro, indicating that the authors' stem and progenitor cells undergo a similar process also in vivo.

TL;DR: It is shown that all-trans retinoic acid treatment alone can induce antitumor effects in vivo, and the potential of differentiation treatment to target the stem-like cell population in glioblastoma is highlighted.

TL;DR: Infiltration of all T-cell subsets increased in high-grade tumors and within pGBM, elevated numbers of intratumoral effector T cells (Teff, cytotoxic and helper) significantly correlated with a better survival; regulatory T cells were infrequently present and not associated with GBM patient outcome.